PA5-29845 targets TBX5 in IF and WB applications and shows reactivity with Human samples.
The PA5-29845 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 243 of Human TBX5.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.
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Protein Aliases: T-box protein 5; T-box transcription factor TBX5
Gene Aliases: HOS; TBX5