This antibody is predicted to react with bovine, canine, mouse, porcine, rat and zebrafish based on sequence homology.
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: FJHN; Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF1 beta A; HNF1B; HNF1beta; HNF2; Homeoprotein LFB3; LFB3; MODY5; TCF-2; TCF2; Transcription factor 2; transcription factor 2, hepatic; transcription factor 2, hepatic LF-B3 variant hepatic nuclear factor; Variant hepatic nuclear factor 1; VHNF1
Gene Aliases: FJHN; HNF-1-beta; HNF-1B; HNF1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1
UniProt ID: (Human) P35680
Entrez Gene ID: (Human) 6928