Keep as concentrated solution.
Positive Control: A549, A549 nuclear extract.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Hepatocyte Nuclear Factor 1 (HNF1, Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor) is a member of the homeodomain-containing superfamily of transcription factors. It is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. HNF1has been shown to function in nephron development and regulates development of the embryonic pancreas. Mutations in the gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of the gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FJHN Antibody; Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B Antibody; HNF1 beta A; HNF1 homeobox B Antibody; HNF1B Antibody; HNF1beta Antibody; HNF2 Antibody; Homeoprotein LFB3; HPC11 Antibody; LF-B3 Antibody; LFB3 Antibody; MODY5 Antibody; TCF-2; TCF-2 Antibody; TCF2 Antibody; Transcription factor 2; transcription factor 2, hepatic; Variant hepatic nuclear factor 1; vHNF1; VHNF1 Antibody
Gene Aliases: FJHN; HNF-1-beta; HNF-1B; HNF1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1
UniProt ID: (Human) P35680
Entrez Gene ID: (Human) 6928