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TCF2 Polyclonal Antibody
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FIGURE: 1 / 2
TCF2 Antibody (PA5-85560) in IHC (P)
TCF2 Polyclonal Antibody detects HNF1 beta protein at nucleus on human ovarian carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human ovarian carcinoma. TCF2 Polyclonal Antibody (Product # PA5-85560) diluted at 1:250. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-85560
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human HNF1 beta. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (94%), Rat (96%), Xenopus laevis (84%), Pig (95%), Rhesus Monkey (98%), Bovine (95%).
Positive Control: A549, A549 nuclear extract.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Hepatocyte Nuclear Factor 1 (HNF1, Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor) is a member of the homeodomain-containing superfamily of transcription factors. It is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. HNF1has been shown to function in nephron development and regulates development of the embryonic pancreas. Mutations in the gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of the gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HNF1 beta A; homeoprotein LFB3; TCF2; transcription factor; transcription factor 2, hepatic; unnamed protein product
Gene Aliases: ADTKD3; FJHN; HNF-1-beta; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; RCAD; T2D; TCF-2; TCF2; VHNF1
UniProt ID: (Human) P35680
Entrez Gene ID: (Human) 6928
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcription cofactor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
protein homodimerization activity
promoter-specific chromatin binding
kidney development
liver development
regulation of transcription from RNA polymerase II promoter
insulin secretion
pancreas development
endocrine pancreas development
regulation of pronephros size
pronephric nephron tubule development
positive regulation of transcription, DNA-templated
animal organ development
system development
pronephros development
genitalia development
positive regulation of transcription initiation from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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