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Proteintech
TCF7 Polyclonal Antibody
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Product Details
14464-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TCF7 Fusion Protein Ag5792 (1-384 aa encoded by BC048769)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPQLDSGGG GAGGGDDLGA PDELLAFQDE GEEQDDKSRD SAAGPERDLA ELKSSLVNES EGAAGGAGIP GVPGAGAGAR GEAEALGREH AAQRLFPDKL PEPLEDGLKA PECTSGMYKE TVYSAFNLLM HYPPPSGAGQ HPQPQPPLHK ANQPPHGVPQ LSLYEHFNSP HPTPAPADIS QKQVHRPLQT PDLSGFYSLT SGSMGQLPHT VSWFTHPSLM LGSGVPGHPA AIPHPAIVPP SGKQELQPFD RNLKTQAESK AEKEAKKPTI KKPLNAFMLY MKEMRAKVIA ECTLKESAAI NQILGRRWHA LSREEQAKYY ELARKERQLH MQLYPGWSAR DNYGKKKRRS REKHQESTTG GKRNAFGTYP EKAAAPAPFL PMTVL (1-384 aa encoded by BC048769)
Target Information
TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HMG-box; OTTHUMP00000159390; OTTHUMP00000159391; T cell factor-1; T-cell factor 1; T-cell specific; T-cell-specific transcription factor 1; TCF-7; Transcription factor 7; transcription factor 7, T-cell specific
Gene Aliases: AI465550; TCF-1; TCF1; TCF7
UniProt ID: (Human) P36402, (Mouse) Q00417
Entrez Gene ID: (Human) 6932, (Mouse) 21414
core promoter binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein binding
beta-catenin binding
sequence-specific DNA binding
transcription regulatory region DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
DNA-binding transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
immune response
neural tube development
embryonic genitalia morphogenesis
T cell receptor V(D)J recombination
regulation of cell proliferation
canonical Wnt signaling pathway involved in negative regulation of apoptotic process
alpha-beta T cell differentiation
embryonic digestive tract morphogenesis
embryonic hindgut morphogenesis
canonical Wnt signaling pathway
cellular response to interleukin-4
beta-catenin-TCF complex assembly
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Wnt signaling pathway
generation of neurons
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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