Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:1,000 | View 3 publications 3 publications |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
TCF7L2 Fusion Protein Ag4786 (1-355 aa encoded by BC032656) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.23 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MPQLNGGGG DDLGANDELI SFKDEGEQEE KSSENSSAER DLADVKSSLV NESETNQNSS SDSEAERRPP PRSESFRDKS RESLEEAAKR QDGGLFKGPP YPGYPFIMIP DLTSPYLPNG SLSPTARTYL QMKWPLLDVQ AGSLQSRQAL KDARSPSPAH IVSNKVPVVQ HPHHVHPLTP LITYSNEHFT PGNPPPHLPA DVDPKTGIPR PPHPPDISPY YPLSPGTVGQ IPHPLGWQGQ PVYPITTGGF RHPYPTALTV NASMSRFPPH MVPPHHTLHT TGIPHPAIVT PTVKQESSQS DVGSLHSSKH QDSKKEEEKK KPHIKKPLNA FMLYMKEMRA KVVAECTLKE SAAINQ (1-355 aa encoded by B C032656)
TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HMG box transcription factor 4; hTCF; hTCF 4; hTCF-4; mTCF-4; RP11-357H24.1; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF 4; TCF7L2 protein; Transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box
Gene Aliases: mTcf-4B; mTcf-4E; TCF-4; TCF4; TCF4B; TCF4E; TCF7L2
UniProt ID: (Human) Q9NQB6, (Mouse) Q924A0
Entrez Gene ID: (Human) 6934, (Rat) 679869, (Mouse) 21416
Molecular Function:
DNA-binding transcription factor
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