Proteintech

TCF7L2 Polyclonal Antibody

23 References
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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

13838-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 18 publications 18 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

-
View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TCF7L2 Fusion Protein Ag4786 (1-355 aa encoded by BC032656)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPQLNGGGG DDLGANDELI SFKDEGEQEE KSSENSSAER DLADVKSSLV NESETNQNSS SDSEAERRPP PRSESFRDKS RESLEEAAKR QDGGLFKGPP YPGYPFIMIP DLTSPYLPNG SLSPTARTYL QMKWPLLDVQ AGSLQSRQAL KDARSPSPAH IVSNKVPVVQ HPHHVHPLTP LITYSNEHFT PGNPPPHLPA DVDPKTGIPR PPHPPDISPY YPLSPGTVGQ IPHPLGWQGQ PVYPITTGGF RHPYPTALTV NASMSRFPPH MVPPHHTLHT TGIPHPAIVT PTVKQESSQS DVGSLHSSKH QDSKKEEEKK KPHIKKPLNA FMLYMKEMRA KVVAECTLKE SAAINQ (1-355 aa encoded by B C032656)

Target Information

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: HMG box transcription factor 4; hTCF; hTCF 4; hTCF-4; mTCF-4; RP11-357H24.1; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF 4; TCF7L2 protein; Transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box

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Gene Aliases: mTcf-4B; mTcf-4E; TCF-4; TCF4; TCF4B; TCF4E; TCF7L2

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UniProt ID: (Human) Q9NQB0, (Mouse) Q924A0

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Entrez Gene ID: (Human) 6934, (Rat) 679869, (Mouse) 21416

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II repressing transcription factor binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding transcription factor binding protein kinase binding nuclear hormone receptor binding sequence-specific DNA binding transcription regulatory region DNA binding gamma-catenin binding armadillo repeat domain binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function chromatin binding DNA binding DNA-binding transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter blood vessel development transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell cycle arrest Wnt signaling pathway, calcium modulating pathway cell proliferation response to glucose positive regulation of heparan sulfate proteoglycan biosynthetic process pancreas development positive regulation of insulin secretion positive regulation of protein binding regulation of hormone metabolic process glucose homeostasis negative regulation of sequence-specific DNA binding transcription factor activity maintenance of DNA repeat elements canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of protein export from nucleus myoblast fate commitment regulation of smooth muscle cell proliferation positive regulation of protein kinase B signaling canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway beta-catenin-TCF complex assembly negative regulation of type B pancreatic cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway cellular glucose homeostasis glycogen metabolic process glucose metabolic process regulation of transcription, DNA-templated transcription from RNA polymerase II promoter biological_process cellular response to starvation post-embryonic development positive regulation of triglyceride biosynthetic process oligodendrocyte development Wnt signaling pathway neural tube development pituitary gland development bone mineralization negative regulation of BMP signaling pathway embryonic genitalia morphogenesis regulation of myelination secretory granule localization somatic stem cell population maintenance multicellular organism growth catenin import into nucleus regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter negative regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth positive regulation of apoptotic process skin development negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of transcription, DNA-templated negative regulation of organ growth positive regulation of lipid biosynthetic process embryonic digestive tract morphogenesis embryonic hindgut morphogenesis regulation of skeletal muscle tissue development regulation of oligodendrocyte differentiation positive regulation of epithelial cell proliferation face morphogenesis regulation of insulin secretion involved in cellular response to glucose stimulus insulin metabolic process generation of neurons
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