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TCF7L2 Polyclonal Antibody
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Product Details
BS-1280R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TCF7L2, amino acids 401-550.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9L, 10, 11, 12, 13, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9L, 10, 11, 12, 15, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9L, 10, 11, 12, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9S, 10, 11, 12, 13, 14, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9S, 10, 11, 12, 13, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9S, 10, 11, 12, 17; contains exons 1, 2, 3, 4, 5, 6, 7S, 8, 9S, 10, 11, 12, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9L, 10, 11, 12, 15, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9L, 10, 11, 12, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9S, 10, 11, 12, 13, 14, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9S, 10, 11, 12, 15, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9S, 10, 11, 12, 17; contains exons 1, 2, 3, 5, 6, 7S, 8, 9S, 10, 11, 12, 17; contains exons 8, 9L, 10, 11, 12, 13, 14, 17; HMG box transcription factor 4; hTCF; hTCF 4; hTCF-4; mTCF-4; RP11-357H24.1; T-cell factor 4; T-cell-specific transcription factor 4; TCF 4; TCF7L2; TCF7L2 protein; transcription factor; Transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box; unnamed protein product
Gene Aliases: mTcf-4B; mTcf-4E; TCF-4; TCF4; TCF4B; TCF4E; TCF7L2
UniProt ID: (Human) Q9NQB0, (Mouse) Q924A0
Entrez Gene ID: (Human) 6934, (Rat) 679869, (Mouse) 21416
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription corepressor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
ligand-dependent nuclear receptor binding
protein kinase binding
sequence-specific DNA binding
gamma-catenin binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
armadillo repeat domain binding
promoter-specific chromatin binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II repressing transcription factor binding
molecular_function
chromatin binding
transcription factor binding
nuclear hormone receptor binding
transcription regulatory region DNA binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
blood vessel development
regulation of transcription from RNA polymerase II promoter
response to glucose
positive regulation of epithelial to mesenchymal transition
positive regulation of heparan sulfate proteoglycan biosynthetic process
Wnt signaling pathway
pancreas development
positive regulation of insulin secretion
regulation of hormone metabolic process
glucose homeostasis
maintenance of DNA repeat elements
fat cell differentiation
negative regulation of gluconeogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
myoblast fate commitment
regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
positive regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of androgen receptor signaling pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of protein localization to nucleus
negative regulation of type B pancreatic cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway
cellular glucose homeostasis
glycogen metabolic process
glucose metabolic process
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
cell cycle arrest
biological_process
cell proliferation
cellular response to starvation
post-embryonic development
positive regulation of triglyceride biosynthetic process
oligodendrocyte development
neural tube development
pituitary gland development
bone mineralization
negative regulation of BMP signaling pathway
embryonic genitalia morphogenesis
regulation of myelination
positive regulation of protein binding
secretory granule localization
somatic stem cell population maintenance
multicellular organism growth
catenin import into nucleus
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
negative regulation of fibroblast growth factor receptor signaling pathway
odontogenesis of dentin-containing tooth
positive regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
skin development
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
negative regulation of fat cell differentiation
positive regulation of gluconeogenesis
positive regulation of transcription, DNA-templated
negative regulation of organ growth
positive regulation of protein export from nucleus
positive regulation of lipid biosynthetic process
embryonic digestive tract morphogenesis
embryonic hindgut morphogenesis
regulation of skeletal muscle tissue development
regulation of oligodendrocyte differentiation
face morphogenesis
regulation of insulin secretion involved in cellular response to glucose stimulus
insulin metabolic process
transcription, DNA-templated
generation of neurons
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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