Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
TCF7L2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
PA5-22989
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide made to an internal portion of human TCF7L2 (within residues 150-200).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 30% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The target sequence has 93% sequence homology with mouse and bovine.
Suggested positive control: TCF7L2 Overexpression lysate, Jurkat whole cell lysate.
Target Information
TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: HMG box transcription factor 4; hTCF; hTCF 4; hTCF-4; RP11-357H24.1; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF 4; TCF7L2 protein; Transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box)
Gene Aliases: TCF-4; TCF4; TCF7L2
UniProt ID: (Human) Q9NQB0
Entrez Gene ID: (Human) 6934
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II repressing transcription factor binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
transcription factor binding
protein kinase binding
nuclear hormone receptor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
gamma-catenin binding
armadillo repeat domain binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
blood vessel development
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell cycle arrest
Wnt signaling pathway, calcium modulating pathway
cell proliferation
response to glucose
positive regulation of heparan sulfate proteoglycan biosynthetic process
pancreas development
positive regulation of insulin secretion
positive regulation of protein binding
regulation of hormone metabolic process
glucose homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
maintenance of DNA repeat elements
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein export from nucleus
myoblast fate commitment
regulation of smooth muscle cell proliferation
positive regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of canonical Wnt signaling pathway
beta-catenin-TCF complex assembly
negative regulation of type B pancreatic cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support