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Invitrogen
TCR delta Monoclonal Antibody (TS-1)
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FIGURE: 1 / 2
TCR delta Antibody (TCR1055) in Flow
Flow cytometry analysis of TCR delta on TCR delta positive PEER cells (left panel) or TCR delta negative HPB-ALL cells (right panel). Equal numbers of cells were stained with a TCR Delta TCS1 (TS-1) monoclonal antibody (Product # TCR1055) followed by FITC labeled secondary antibody, or FITC labeled secondary antibody alone (black histograms). 5 µL of primary antibody were used per test. All antibody incubations were performed for 30 minutes at room temperature. A representative 10,000 cells were acquired for each sample.
Product Details
TCR1055
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
TS-1
Immunogen
Human TCR Vdelta1-Jdelta1
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Amount
200 µg
Purification
purified
Storage buffer
PBS with 0.5% BSA
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
TCR1055 targets TCR Delta TCS1 in FACS, IHC(F), IP, and TCA applications and shows reactivity with Human samples.
The TCR1055 immunogen is human TCR Vdelta1-Jdelta1.
TCR1055 detects TCR Delta TCS1 which has a predicted molecular weight of approximately 17 kDa.
Target Information
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD3 antigen; CD3d antigen; OKT3
Gene Aliases: hDV101S1
Entrez Gene ID: (Human) 28518
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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