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Invitrogen
TCR gamma/delta Monoclonal Antibody (5A6.E9)
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FIGURE: 1 / 2
TCR gamma/delta Antibody (TCR1061) in Flow
Flow cytometry analysis of TCR gamma/delta on TCR gamma/delta positive PEER cells or TCR gamma/delta negative Jurkat cells. Equal numbers of cells were stained with a TCR gamma + delta (5A6.E9) monoclonal antibody (Product # TCR1061) followed by FITC labeled secondary antibody or with FITC labeled secondary antibody alone (black histograms). 5 µL of primary antibody were used per test. All antibody incubations were performed for 30 minutes at room temperature. A representative 10,000 cells were acquired for each sample.
Product Details
TCR1061
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Cynomolgus monkey,
Human,
Non-human primate,
Rhesus monkey
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5A6.E9
Immunogen
Human leukemic PEER cells
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Amount
200 µg
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
TCR1061 targets TCR Pan TCR gamma delta in FACS, IHC(F), IP, and TCA applications and shows reactivity with Human samples. The clone 5A6.E9 has been listed as 5A6.E91 in some publications and documents. These are the same clone.
The TCR1061 immunogen is human PEER cells.
TCR1061 detects TCR Pan TCR gamma delta which has a predicted molecular weight of approximately 18 kDa.
Target Information
TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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