Product References
Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.
Disease models & mechanisms
Wang J,Thomas HR,Thompson RG,Waldrep SC,Fogerty J,Song P,Li Z,Ma Y,Santra P,Hoover JD,Yeo NC,Drummond IA,Yoder BK,Amack JD,Perkins B,Parant JM
Thu Dec 01 00:00:00 UTC 2022
The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.
Cell reports
Schembs L,Willems A,Hasenpusch-Theil K,Cooper JD,Whiting K,Burr K,Bøstrand SMK,Selvaraj BT,Chandran S,Theil T
Tue May 17 00:00:00 UTC 2022
Superresolution Microscopy Reveals Distinct Phosphoinositide Subdomains Within the Cilia Transition Zone.
Frontiers in cell and developmental biology
Conduit SE,Davies EM,Fulcher AJ,Oorschot V,Mitchell CA
Tue May 18 00:00:00 UTC 2021
Disrupted intraflagellar transport due to IFT74 variants causes Joubert syndrome.
Genetics in medicine : official journal of the American College of Medical Genetics
Luo M,Lin Z,Zhu T,Jin M,Meng D,He R,Cao Z,Shen Y,Lu C,Cai R,Zhao Y,Wang X,Li H,Wu S,Zou X,Luo G,Cao L,Huang M,Jiao H,Gao H,Sui R,Zhao C,Ma X,Cao M
Tue Jun 01 00:00:00 UTC 2021
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
Science advances
Chen C,Xu Q,Zhang Y,Davies BA,Huang Y,Katzmann DJ,Harris PC,Hu J,Ling K
Tue Jun 01 00:00:00 UTC 2021
Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry.
Biology open
Qiu H,Fujisawa S,Nozaki S,Katoh Y,Nakayama K
Mon Jan 25 00:00:00 UTC 2021
TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating.
Nature communications
Yan H,Chen C,Chen H,Hong H,Huang Y,Ling K,Hu J,Wei Q
Mon May 04 00:00:00 UTC 2020
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
Developmental cell
Ran J,Liu M,Feng J,Li H,Ma H,Song T,Cao Y,Zhou P,Wu Y,Yang Y,Yang Y,Yu F,Guo H,Zhang L,Xie S,Li D,Gao J,Zhang X,Zhu X,Zhou J
Mon May 04 00:00:00 UTC 2020
ESCRT subunit CHMP4B localizes to primary cilia and is required for the structural integrity of the ciliary membrane.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jung E,Choi TI,Lee JE,Kim CH,Kim J
Wed Jan 01 00:00:00 UTC 2020
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
The EMBO journal
Wiegering A,Dildrop R,Kalfhues L,Spychala A,Kuschel S,Lier JM,Zobel T,Dahmen S,Leu T,Struchtrup A,Legendre F,Vesque C,Schneider-Maunoury S,Saunier S,Rüther U,Gerhardt C
Tue May 15 00:00:00 UTC 2018
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
The EMBO journal
Wiegering A,Dildrop R,Kalfhues L,Spychala A,Kuschel S,Lier JM,Zobel T,Dahmen S,Leu T,Struchtrup A,Legendre F,Vesque C,Schneider-Maunoury S,Saunier S,Rüther U,Gerhardt C
Tue May 15 00:00:00 UTC 2018
NUP98 Sets the Size-Exclusion Diffusion Limit through the Ciliary Base.
Current biology : CB
Endicott SJ,Brueckner M
Mon May 21 00:00:00 UTC 2018
NUP98 Sets the Size-Exclusion Diffusion Limit through the Ciliary Base.
Current biology : CB
Endicott SJ,Brueckner M
Mon May 21 00:00:00 UTC 2018
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
Nature communications
Tu HQ,Qin XH,Liu ZB,Song ZQ,Hu HB,Zhang YC,Chang Y,Wu M,Huang Y,Bai YF,Wang G,Han QY,Li AL,Zhou T,Liu F,Zhang XM,Li HY
Tue Dec 11 00:00:00 UTC 2018
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
eLife
Vuolo L,Stevenson NL,Heesom KJ,Stephens DJ
Tue Oct 16 00:00:00 UTC 2018
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
eLife
Vuolo L,Stevenson NL,Heesom KJ,Stephens DJ
Tue Oct 16 00:00:00 UTC 2018
Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.
Nature genetics
Lu H,Galeano MCR,Ott E,Kaeslin G,Kausalya PJ,Kramer C,Ortiz-Brüchle N,Hilger N,Metzis V,Hiersche M,Tay SY,Tunningley R,Vij S,Courtney AD,Whittle B,Wühl E,Vester U,Hartleben B,Neuber S,Frank V,Little MH,Epting D,Papathanasiou P,Perkins AC,Wright GD,Hunziker W,Gee HY,Otto EA,Zerres K,Hildebrandt F,Roy S,Wicking C,Bergmann C
Sat Jul 01 00:00:00 UTC 2017
Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.
Nature genetics
Lu H,Galeano MCR,Ott E,Kaeslin G,Kausalya PJ,Kramer C,Ortiz-Brüchle N,Hilger N,Metzis V,Hiersche M,Tay SY,Tunningley R,Vij S,Courtney AD,Whittle B,Wühl E,Vester U,Hartleben B,Neuber S,Frank V,Little MH,Epting D,Papathanasiou P,Perkins AC,Wright GD,Hunziker W,Gee HY,Otto EA,Zerres K,Hildebrandt F,Roy S,Wicking C,Bergmann C
Sat Jul 01 00:00:00 UTC 2017
Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.
Current biology : CB
Hamel V,Steib E,Hamelin R,Armand F,Borgers S,Flückiger I,Busso C,Olieric N,Sorzano COS,Steinmetz MO,Guichard P,Gönczy P
Mon Aug 21 00:00:00 UTC 2017
Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.
Current biology : CB
Hamel V,Steib E,Hamelin R,Armand F,Borgers S,Flückiger I,Busso C,Olieric N,Sorzano COS,Steinmetz MO,Guichard P,Gönczy P
Mon Aug 21 00:00:00 UTC 2017
A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.
Oncogene
Conduit SE,Ramaswamy V,Remke M,Watkins DN,Wainwright BJ,Taylor MD,Mitchell CA,Dyson JM
Thu Oct 26 00:00:00 UTC 2017
A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.
Oncogene
Conduit SE,Ramaswamy V,Remke M,Watkins DN,Wainwright BJ,Taylor MD,Mitchell CA,Dyson JM
Thu Oct 26 00:00:00 UTC 2017
INPP5E regulates phosphoinositide-dependent cilia transition zone function.
The Journal of cell biology
Dyson JM,Conduit SE,Feeney SJ,Hakim S,DiTommaso T,Fulcher AJ,Sriratana A,Ramm G,Horan KA,Gurung R,Wicking C,Smyth I,Mitchell CA
Mon Jan 02 00:00:00 UTC 2017
INPP5E regulates phosphoinositide-dependent cilia transition zone function.
The Journal of cell biology
Dyson JM,Conduit SE,Feeney SJ,Hakim S,DiTommaso T,Fulcher AJ,Sriratana A,Ramm G,Horan KA,Gurung R,Wicking C,Smyth I,Mitchell CA
Mon Jan 02 00:00:00 UTC 2017
Loss of OCRL increases ciliary PI(4,5)P2 in Lowe oculocerebrorenal syndrome.
Journal of cell science
Prosseda PP,Luo N,Wang B,Alvarado JA,Hu Y,Sun Y
Sun Oct 15 00:00:00 UTC 2017
Loss of OCRL increases ciliary PI(4,5)P2 in Lowe oculocerebrorenal syndrome.
Journal of cell science
Prosseda PP,Luo N,Wang B,Alvarado JA,Hu Y,Sun Y
Sun Oct 15 00:00:00 UTC 2017
Immunofluorescent staining of septins in primary cilia.
Methods in cell biology
Kim MS,Froese CD,Xie H,Trimble WS
Mon Aug 21 00:00:00 UTC 2017
Immunofluorescent staining of septins in primary cilia.
Methods in cell biology
Kim MS,Froese CD,Xie H,Trimble WS
Mon Aug 21 00:00:00 UTC 2017
Role for the IFT-A Complex in Selective Transport to the Primary Cilium.
Cell reports
Fu W,Wang L,Kim S,Li J,Dynlacht BD
Tue Nov 01 00:00:00 UTC 2016
Role for the IFT-A Complex in Selective Transport to the Primary Cilium.
Cell reports
Fu W,Wang L,Kim S,Li J,Dynlacht BD
Tue Nov 01 00:00:00 UTC 2016
Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.
Nature communications
Xu Q,Zhang Y,Wei Q,Huang Y,Hu J,Ling K
Fri Feb 26 00:00:00 UTC 2016
Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.
Nature communications
Xu Q,Zhang Y,Wei Q,Huang Y,Hu J,Ling K
Fri Feb 26 00:00:00 UTC 2016
Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.
Human molecular genetics
Barbelanne M,Hossain D,Chan DP,Peränen J,Tsang WY
Wed Apr 15 00:00:00 UTC 2015
Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.
Human molecular genetics
Barbelanne M,Hossain D,Chan DP,Peränen J,Tsang WY
Wed Apr 15 00:00:00 UTC 2015
A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.
Developmental biology
Lu H,Toh MT,Narasimhan V,Thamilselvam SK,Choksi SP,Roy S
Thu Jan 15 00:00:00 UTC 2015
A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.
Developmental biology
Lu H,Toh MT,Narasimhan V,Thamilselvam SK,Choksi SP,Roy S
Thu Jan 15 00:00:00 UTC 2015
CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.
Nature cell biology
Wang WJ,Tay HG,Soni R,Perumal GS,Goll MG,Macaluso FP,Asara JM,Amack JD,Tsou MF
Sat Jun 01 00:00:00 UTC 2013
CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.
Nature cell biology
Wang WJ,Tay HG,Soni R,Perumal GS,Goll MG,Macaluso FP,Asara JM,Amack JD,Tsou MF
Sat Jun 01 00:00:00 UTC 2013
CCDC41 is required for ciliary vesicle docking to the mother centriole.
Proceedings of the National Academy of Sciences of the United States of America
Joo K,Kim CG,Lee MS,Moon HY,Lee SH,Kim MJ,Kweon HS,Park WY,Kim CH,Gleeson JG,Kim J
Tue Apr 09 00:00:00 UTC 2013
CCDC41 is required for ciliary vesicle docking to the mother centriole.
Proceedings of the National Academy of Sciences of the United States of America
Joo K,Kim CG,Lee MS,Moon HY,Lee SH,Kim MJ,Kweon HS,Park WY,Kim CH,Gleeson JG,Kim J
Tue Apr 09 00:00:00 UTC 2013
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Nature genetics
Garcia-Gonzalo FR,Corbit KC,Sirerol-Piquer MS,Ramaswami G,Otto EA,Noriega TR,Seol AD,Robinson JF,Bennett CL,Josifova DJ,García-Verdugo JM,Katsanis N,Hildebrandt F,Reiter JF
Sun Jul 03 00:00:00 UTC 2011
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Nature genetics
Garcia-Gonzalo FR,Corbit KC,Sirerol-Piquer MS,Ramaswami G,Otto EA,Noriega TR,Seol AD,Robinson JF,Bennett CL,Josifova DJ,García-Verdugo JM,Katsanis N,Hildebrandt F,Reiter JF
Sun Jul 03 00:00:00 UTC 2011
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.
Nature cell biology
Chih B,Liu P,Chinn Y,Chalouni C,Komuves LG,Hass PE,Sandoval W,Peterson AS
Sun Dec 18 00:00:00 UTC 2011
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.
Nature cell biology
Chih B,Liu P,Chinn Y,Chalouni C,Komuves LG,Hass PE,Sandoval W,Peterson AS
Sun Dec 18 00:00:00 UTC 2011
