TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 21 kDa polypeptide; 21 kDa polypeptide under translational control; Fortilin; Histamine-releasing factor; HRF; Lens epithelial protein; p21; p23; TCTP; translationally regulated transcript (21 kDa); Translationally-controlled tumor protein
Gene Aliases: HRF; p02; p21; p23; TCTP; TPT1; Trt
Molecular Function: non-motor microtubule binding protein