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Invitrogen
TDO2 Polyclonal Antibody
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Product Details
PA5-42759
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human TDO2 (aa 1-50).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: MSGCPFLGNN FGYTFKKLPV EGSEEDKSQT GVNRASKGGL IYGNYLHLEK
Sequence homology: Dog: 79%; Human: 100%; Pig: 92%
Target Information
Tryptophan 2,3-dioxygenase (TDO2) is an enzyme encoded by the TDO2 gene, predominantly expressed in the liver and playing a crucial role in tryptophan metabolism through the kynurenine pathway. TDO2 catalyzes the first and rate-limiting step of this pathway, converting tryptophan into N-formylkynurenine. This metabolic process is vital for maintaining systemic tryptophan homeostasis and regulating its availability for protein synthesis and serotonin production. Beyond its metabolic function, TDO2 is involved in modulating immune responses. It contributes to immune tolerance by depleting tryptophan, thereby inhibiting T cell proliferation and promoting regulatory T cell development. Recent research has identified TDO2's role in cancer, particularly in shaping the tumor microenvironment and facilitating immune escape mechanisms through tryptophan catabolism. Its expression is upregulated in several cancers, including gliomas, correlating with tumor severity and patient prognosis. TDO2 and its associated pathways have become therapeutic targets in cancer immunotherapy due to their influence on immune system modulation and metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: TDO; TO; Tryptamin 2,3-dioxygenase; Tryptophan 2,3-dioxygenase; Tryptophan oxygenase; Tryptophan pyrrolase; Tryptophanase; unnamed protein product
Gene Aliases: HYPTRP; TDO; TDO2; TO; TPH2; TRPO
UniProt ID: (Human) P48775
Entrez Gene ID: (Human) 6999
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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