Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CXXC finger 6; CXXC-type zinc finger protein 6; Methylcytosine dioxygenase TET1; Ten-eleven translocation 1 gene protein homolog; tet oncogene 1
Gene Aliases: 2510010B09Rik; AA517754; BB001228; Cxxc6; D10Ertd17e; Kiaa1676; LCX; mKIAA1676; Tet1
UniProt ID: (Mouse) Q3URK3
Entrez Gene ID: (Mouse) 52463