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Invitrogen
TET1 Polyclonal Antibody
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FIGURE: 1 / 8
TET1 Antibody (PA5-85489) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of TET1 was performed in Mock and transfected 293T cells fixed in 4% paraformaldehyde at RT for 15 min. Green: TET1 Polyclonal Antibody (Product # PA5-85489) diluted at 1:1000. Blue: Hoechst 33342 staining.
Product Details
PA5-85489
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human TET1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.01 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2792629
Product Specific Information
Keep as concentrated solution.
Positive Control: 293T, A431, HeLa, HepG2, 293T tagged-hTET1, DDDDK-human TET1-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CXXC finger 6; CXXC zinc finger 6; CXXC-type zinc finger protein 6; Leukemia-associated protein with a CXXC domain; Methylcytosine dioxygenase TET1; RP11-119F7.1; Ten-eleven translocation 1 gene protein; Ten-eleven translocation 1 gene protein homolog; ten-eleven translocation-1; tet oncogene 1; TET1 splice variant VP_DE4; TET1 splice variant VP_DE456
Gene Aliases: 2510010B09Rik; AA517754; bA119F7.1; BB001228; CXXC6; D10Ertd17e; KIAA1676; LCX; mKIAA1676; MLL-TET1; TET1; TET1-MLL
UniProt ID: (Human) Q8NFU7, (Mouse) Q3URK3
Entrez Gene ID: (Human) 80312, (Mouse) 52463
inner cell mass cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein O-linked glycosylation
chromatin modification
stem cell population maintenance
regulation of DNA methylation
positive regulation of transcription from RNA polymerase II promoter
oxidation-reduction process
DNA demethylation
negative regulation of methylation-dependent chromatin silencing
regulation of genetic imprinting
positive regulation of cell proliferation
covalent chromatin modification
positive regulation of histone methylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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