Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: LHAQPQPQH PGWPGQRQSQ ESGLLHTHRG LPHQLSGLDP RRDYRRHEDL LHGPHALSSG LGDLSIHSLP HAIEEVPHVE DPGINIPDQT VIKKGPVSLS KSNSNAVSAI PINKDNLFGG VVNPNEVFCS VPGRLSLLSS TSKYKVTVAE VQRRLSPPEC LNASLLGGVL RRAKSKNGGR SLREKLDKIG LNLPAGRRKA ANVTLLTSLV EGEAVHLARD FGYVCETEFP AKAVAEFLNR QHSDPNEQVT RKNMLLATKQ ICKEFTDLLA QDRSPLGNSR PNPILEPGIQ SCLTHFNLIS HGFGSPAVCA AVTALQNYLT EALKAMDKMY LSNNPNSHTD NNAKSSDKEE KHRK (79-431 aa encoded by BC017754)
TFAP2A is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2A is the only AP-2 protein required for early morphogenesis of the lens vesicle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2; AP-2 transcription factor; AP2-alpha; FLJ51761; OTTHUMP00000214240; OTTHUMP00000214243; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Transcription factor AP-2-alpha
Gene Aliases: AP-2; AP-2alpha; AP2TF; BOFS; TFAP2; TFAP2A
UniProt ID: (Human) P05549
Entrez Gene ID: (Human) 7020
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