Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
TFEB Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
13372-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TFEB Fusion Protein Ag4194 (1-476 aa encoded by BC032448)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This is a rabbit polyclonal antibody raised against the full length of human TFEB. The calculated molecular weight of TFEB is 53 kDa, but modified TFEB is about 65-70 kDa.
Immunogen sequence: MASRIGLRM QLMREQAQQE EQRERMQQQA VMHYMQQQQQ QQQQQLGGPP TPAINTPVHF QSPPPVPGEV LKVQSYLENP TSYHLQQSQH QKVREYLSET YGNKFAAHIS PAQGSPKPPP AASPGVRAGH VLSSSAGNSA PNSPMAMLHI GSNPERELDD VIDNIMRLDD VLGYINPEMQ MPNTLPLSSS HLNVYSSDPQ VTASLVGVTS SSCPADLTQK RELTDAESRA LAKERQKKDN HNLIERRRRF NINDRIKELG MLIPKANDLD VRWNKGTILK ASVDYIRRMQ KDLQKSRELE NHSRRLEMTN KQLWLRIQEL EMQARVHGLP TTSPSGMNMA ELAQQVVKQE LPSEEGPGEA LMLGAEVPDP EPLPALPPQA PLPLPTQPPS PFHHLDFSHS LSFGGREDEG PPGYPEPLAP GHGSPFPSLS KKDLDLMLLD DSLLPLASDP LLSTMSPEAS KASSRRSSFS MEEGDVL (1-476 aa encoded by BC032448)
Target Information
The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors. Recent studies have shown that lysosomal biogenesis is regulated by TFEB, which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1. Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha TCFEB; bHLHe35; Class E basic helix-loop-helix protein 35; RP4-696P19.3; T-cell transcription factor EB; Transcription factor EB
Gene Aliases: ALPHATFEB; BHLHE35; TCFEB; TFEB
UniProt ID: (Human) P19484, (Mouse) Q9R210
Entrez Gene ID: (Human) 7942, (Rat) 316214, (Mouse) 21425
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
protein dimerization activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
protein heterodimerization activity
embryonic placenta development
adaptive immune response
transcription, DNA-templated
regulation of transcription, DNA-templated
autophagy
humoral immune response
lysosome organization
positive regulation of autophagy
positive regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
immune system process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support