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Proteintech
TFEB Polyclonal Antibody
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Product Details
13372-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TFEB Fusion Protein Ag4194 (1-476 aa encoded by BC032448)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This is a rabbit polyclonal antibody raised against the full length of human TFEB. The calculated molecular weight of TFEB is 53 kDa, but modified TFEB is about 65-70 kDa.
Immunogen sequence: MASRIGLRM QLMREQAQQE EQRERMQQQA VMHYMQQQQQ QQQQQLGGPP TPAINTPVHF QSPPPVPGEV LKVQSYLENP TSYHLQQSQH QKVREYLSET YGNKFAAHIS PAQGSPKPPP AASPGVRAGH VLSSSAGNSA PNSPMAMLHI GSNPERELDD VIDNIMRLDD VLGYINPEMQ MPNTLPLSSS HLNVYSSDPQ VTASLVGVTS SSCPADLTQK RELTDAESRA LAKERQKKDN HNLIERRRRF NINDRIKELG MLIPKANDLD VRWNKGTILK ASVDYIRRMQ KDLQKSRELE NHSRRLEMTN KQLWLRIQEL EMQARVHGLP TTSPSGMNMA ELAQQVVKQE LPSEEGPGEA LMLGAEVPDP EPLPALPPQA PLPLPTQPPS PFHHLDFSHS LSFGGREDEG PPGYPEPLAP GHGSPFPSLS KKDLDLMLLD DSLLPLASDP LLSTMSPEAS KASSRRSSFS MEEGDVL (1-476 aa encoded by BC032448)
Target Information
The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors. Recent studies have shown that lysosomal biogenesis is regulated by TFEB, which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1. Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha TCFEB; bHLHe35; Class E basic helix-loop-helix protein 35; RP4-696P19.3; T-cell transcription factor EB; TFEB protein; Transcription factor EB; unnamed protein product
Gene Aliases: ALPHATFEB; BHLHE35; TCFEB; TFEB
UniProt ID: (Human) P19484, (Mouse) Q9R210
Entrez Gene ID: (Human) 7942, (Rat) 316214, (Mouse) 21425
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
enzyme binding
protein heterodimerization activity
protein dimerization activity
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription regulatory region DNA binding
embryonic placenta development
adaptive immune response
immune system process
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
autophagy
humoral immune response
lysosome organization
cellular response to starvation
positive regulation of autophagy
lysosome localization
cellular response to amino acid starvation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
defense response to Gram-negative bacterium
antibacterial innate immune response
regulation of lysosome organization
transcription from RNA polymerase II promoter
transcription, DNA-templated
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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