MA1-21595 detects TGF beta in Human samples.
MA1-21595 has been successfully used in Neutralization, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin) and Western Blot procedures. By Western blot, this antibody detects detects dimeric (25 kDa) and monomeric (12.5 kDa) forms of TGF beta, under non-reducing and reducing conditions, respectively
MA1-21595 immunogen corresponds to TGF-beta 1 from human platelets.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CED; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; TGF-beta-1; TGFB; TGFbeta; Transforming growth factor beta-1; Transforming growth factor beta-1 proprotein
Gene Aliases: CED; DPD1; LAP; TGFB; TGFB1; TGFbeta
UniProt ID: (Human) P01137
Entrez Gene ID: (Human) 7040