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          • Primary Antibodies ›
          • TGF beta-2 Antibodies

          Invitrogen

          TGF beta-2 Polyclonal Antibody

          View all (14) TGF beta-2 antibodies

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          Cite TGF beta-2 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (1)
          TGF beta-2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          TGF beta-2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          TGF beta-2 Antibody (PA5-92040) in WB

          Western blot analysis of TGF beta-2 in extracts of various cell lines. Samples were incubated with TGF beta-2 Polyclonal antibody (Product # PA5-92040) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          TGF beta-2 Antibody in Western Blot (WB)
          TGF beta-2 Polyclonal Antibody

          Product Details

          PA5-92040

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          -

          ELISA (ELISA)

          1 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human TGFB2 (NP_0011290711)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1.41 mg/mL

          Purification

          Affinity Chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.09% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2806362

          Product Specific Information

          Positive Samples: A-549, Mouse heart

          Immunogen sequence: SLSTCSTLDM DQFMRKRIEA IRGQILSKLK LTSPPEDYPE PEEVPPEVIS IYNSTRDLLQ EKASRRAAAC ERERSDEEYY AKEVYKIDMP PFFPSETVCP VVTTPSGSVG SLCSRQSQVL CGYLDAIPPT FYRPYFRIVR F

          Target Information

          Transforming Growth Factor (TGF) betas mediate many cell to cell interactions that occur during embryonic development. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule. The TGF beta polypeptides are multifunctional; capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed, as well as nonneoplastic tissues, release transforming growth factors; and essentially all mammalian cells possess a specific TGF receptor. The multi modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide. TGF beta 1, TGF beta 2, and TGF beta 1.2 appear to be equivalent in biological activity, although there does appear to be differences in binding to certain types of receptors. TGF beta 2 is produced by many cell types and has been found in the highest concentration in porcine platelets and mammalian bone. Latent TGF beta 2 is the prominent isoform found in body fluids such as amniotic fluid, breast milk, and the aqueous and vitreous humor of the eye.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: BSC-1 cell growth inhibitor; Cetermin; G-TSF; Glioblastoma-derived T-cell suppressor factor; polyergin; prepro-transforming growth factor beta-2; TGF beta 2 protein; TGF-beta-2; TGFB; TGFβ2; Transforming growth factor; transforming growth factor beta-2; Transforming growth factor beta-2 proprotein; transforming growth factor-beta-2 precursor; unnamed protein product

          View more View less

          Gene Aliases: BB105277; G-TSF; LDS4; TGF-B2; TGF-beta2; Tgfb-2; TGFB2

          View more View less

          UniProt ID: (Human) P61812, (Mouse) P27090, (Rat) Q07257

          View more View less

          Entrez Gene ID: (Human) 7042, (Mouse) 21808, (Rat) 81809

          View more View less

          Function(s)
          beta-amyloid binding receptor binding type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity type III transforming growth factor beta receptor binding protein homodimerization activity receptor signaling protein serine/threonine kinase activity protein heterodimerization activity protein N-terminus binding growth factor
          Process(es)
          cell morphogenesis skeletal system development cartilage condensation blood vessel development eye development response to hypoxia kidney development epithelial to mesenchymal transition neural tube closure hair follicle development blood vessel remodeling heart morphogenesis outflow tract septum morphogenesis membranous septum morphogenesis outflow tract morphogenesis heart valve morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis endocardial cushion fusion atrial septum primum morphogenesis neural retina development activation-induced cell death of T cells transforming growth factor beta receptor signaling pathway axon guidance sensory organ development salivary gland morphogenesis heart development positive regulation of cell proliferation negative regulation of cell proliferation glial cell migration male gonad development response to wounding embryo development ending in birth or egg hatching cardioblast differentiation positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration positive regulation of epithelial to mesenchymal transition negative regulation of macrophage cytokine production striated muscle tissue development cell migration negative regulation of angiogenesis signaling hemopoiesis extracellular matrix organization collagen fibril organization positive regulation of cell growth negative regulation of cell growth embryonic limb morphogenesis neutrophil chemotaxis epithelial cell differentiation hair follicle morphogenesis response to progesterone positive regulation of stress-activated MAPK cascade regulation of transforming growth factor beta2 production regulation of actin cytoskeleton organization positive regulation of cell adhesion mediated by integrin ascending aorta morphogenesis wound healing regulation of cell proliferation dopamine biosynthetic process odontogenesis uterine wall breakdown regulation of apoptotic process positive regulation of apoptotic process positive regulation of neuron apoptotic process cell-cell junction organization positive regulation of cell differentiation positive regulation of integrin biosynthetic process positive regulation of Notch signaling pathway positive regulation of cell cycle positive regulation of heart contraction negative regulation of Ras protein signal transduction somatic stem cell division embryonic digestive tract development neuron fate commitment neuron development generation of neurons inner ear development negative regulation of epithelial cell proliferation positive regulation of protein secretion positive regulation of immune response positive regulation of cellular component organization positive regulation of multicellular organismal process positive regulation of cell division regulation of timing of catagen positive regulation of catagen positive regulation of cardioblast differentiation positive regulation of protein kinase B signaling cardiac muscle cell proliferation uterus development cardiac epithelial to mesenchymal transition face morphogenesis positive regulation of SMAD protein import into nucleus ventricular septum morphogenesis atrial septum morphogenesis negative regulation of cartilage development pharyngeal arch artery morphogenesis secondary palate development positive regulation of cardiac epithelial to mesenchymal transition positive regulation of activation-induced cell death of T cells cellular response to growth factor stimulus positive regulation of extracellular matrix disassembly extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand transforming growth factor beta receptor superfamily signaling pathway positive regulation of protein localization to nucleus regulation of apoptotic process involved in outflow tract morphogenesis positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of extracellular matrix organization regulation of complement-dependent cytotoxicity substantia propria of cornea development pericyte cell differentiation cranial skeletal system development negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of extrinsic apoptotic signaling pathway in absence of ligand cardiac left ventricle morphogenesis protein phosphorylation cell cycle arrest SMAD protein import into nucleus cell death negative regulation of alkaline phosphatase activity positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of phosphatidylinositol 3-kinase signaling cell growth signal transduction by protein phosphorylation positive regulation of cell migration activation of protein kinase activity intracellular signal transduction growth response to drug catagen negative regulation of apoptotic process regulation of MAPK cascade response to estrogen negative regulation of keratinocyte differentiation embryonic neurocranium morphogenesis negative regulation of immune response negative regulation of release of sequestered calcium ion into cytosol pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction regulation of cell growth skeletal muscle tissue development female pregnancy aging response to radiation response to cold response to organonitrogen compound lung development thyroid gland development hindbrain development pancreas development response to estradiol response to retinoic acid response to vitamin D response to cytokine response to laminar fluid shear stress positive regulation of ossification cell development digestive tract development frontal suture morphogenesis
          It has to be done as per old AB suggested Products section.

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