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Invitrogen
TGF beta-3 Polyclonal Antibody
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Product Details
PA5-49752
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human TGF beta3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total TGF beta-3 protein.
Target Information
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ16571; H-TGF-b-3; prepro-transforming growth factor beta-3; tgf beta 3; TGF-beta-3; Transforming growth factor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3
Gene Aliases: ARVD; ARVD1; LDS5; RNHF; TGF-B3; TGF-beta3; Tgfb-3; TGFB3
UniProt ID: (Human) P10600, (Rat) Q07258
Entrez Gene ID: (Human) 7043, (Rat) 25717, (Mouse) 21809
type II transforming growth factor beta receptor binding
cytokine activity
protein binding
growth factor activity
type I transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding
identical protein binding
protein heterodimerization activity
transforming growth factor beta binding
transforming growth factor beta receptor binding
growth factor
activation of MAPK activity
response to hypoxia
in utero embryonic development
platelet degranulation
transforming growth factor beta receptor signaling pathway
SMAD protein import into nucleus
salivary gland morphogenesis
female pregnancy
aging
negative regulation of DNA replication
negative regulation of cell proliferation
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of macrophage cytokine production
cell growth
positive regulation of bone mineralization
negative regulation of transforming growth factor beta receptor signaling pathway
mammary gland development
response to progesterone
positive regulation of collagen biosynthetic process
response to laminar fluid shear stress
wound healing
regulation of cell proliferation
odontogenesis
uterine wall breakdown
regulation of apoptotic process
positive regulation of apoptotic process
regulation of MAPK cascade
negative regulation of neuron apoptotic process
response to estrogen
ossification involved in bone remodeling
cell-cell junction organization
positive regulation of DNA replication
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
digestive tract development
embryonic neurocranium morphogenesis
inner ear development
positive regulation of protein secretion
positive regulation of filopodium assembly
positive regulation of stress fiber assembly
positive regulation of cell division
palate development
face morphogenesis
frontal suture morphogenesis
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
detection of hypoxia
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of occluding junction disassembly
organ morphogenesis
lung development
regulation of epithelial cell differentiation
regulation of endothelial cell differentiation
cell development
regulation of epithelial cell proliferation
cellular response to growth factor stimulus
embryo development
growth
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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