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Invitrogen
TGFBR1 Polyclonal Antibody
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FIGURE: 1 / 2
TGFBR1 Antibody (PA5-14959) in IHC (P)
Immunohistochemistry analysis of TGFBR1 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with TGFBR1 polyclonal antibody (Product # PA5-14959) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = he... View More
Product Details
PA5-14959
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 134-163 amino acids from the central region of human TGF Beta Receptor I
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
400 µg
Purification
Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, porcine and rat based on sequence homology.
Target Information
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: activin A receptor type II-like kinase, 53kDa; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; mutant transforming growth factor beta receptor I; ser; Serine/threonine-protein kinase receptor R4; SKR4; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; TGFR1; Transfor; transforming growth factor beta receptor I; Transforming growth factor-beta receptor type I; unnamed protein product
Gene Aliases: AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFBR1; TGFR-1
UniProt ID: (Human) P36897
Entrez Gene ID: (Human) 7046
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type I
receptor binding
type II transforming growth factor beta receptor binding
protein binding
ATP binding
kinase activity
activin receptor activity, type I
transferase activity
growth factor binding
ubiquitin protein ligase binding
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding
I-SMAD binding
skeletal system development
angiogenesis
in utero embryonic development
kidney development
blastocyst development
epithelial to mesenchymal transition
endothelial cell proliferation
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
lens development in camera-type eye
ventricular trabecula myocardium morphogenesis
ventricular compact myocardium morphogenesis
proepicardium development
regulation of transcription, DNA-templated
apoptotic process
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
nervous system development
heart development
positive regulation of cell proliferation
germ cell migration
male gonad development
post-embryonic development
anterior/posterior pattern specification
regulation of gene expression
positive regulation of gene expression
regulation of epithelial to mesenchymal transition
positive regulation of epithelial to mesenchymal transition
peptidyl-serine phosphorylation
cell differentiation
collagen fibril organization
positive regulation of cell growth
regulation of cell migration
positive regulation of cell migration
negative regulation of cell migration
regulation of protein ubiquitination
negative regulation of chondrocyte differentiation
activin receptor signaling pathway
intracellular signal transduction
myofibroblast differentiation
wound healing
endothelial cell activation
extracellular structure organization
positive regulation of apoptotic process
negative regulation of apoptotic process
endothelial cell migration
positive regulation of transcription, DNA-templated
filopodium assembly
thymus development
neuron fate commitment
embryonic cranial skeleton morphogenesis
skeletal system morphogenesis
mesenchymal cell differentiation
artery morphogenesis
cell motility
positive regulation of filopodium assembly
positive regulation of stress fiber assembly
regulation of cell cycle
positive regulation of protein kinase B signaling
parathyroid gland development
palate development
pharyngeal system development
regulation of cardiac muscle cell proliferation
cardiac epithelial to mesenchymal transition
positive regulation of SMAD protein import into nucleus
ventricular septum morphogenesis
angiogenesis involved in coronary vascular morphogenesis
coronary artery morphogenesis
trophoblast cell migration
response to cholesterol
cellular response to growth factor stimulus
cellular response to transforming growth factor beta stimulus
response to alcohol
vascular endothelial cell proliferation
positive regulation of extracellular matrix assembly
positive regulation of mesenchymal stem cell proliferation
positive regulation of vasculature development
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of occluding junction disassembly
epicardium morphogenesis
regulation of multicellular organismal development
positive regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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