Search
Proteintech
TGFBR2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
27212-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TGFBR2 Fusion Protein Ag25767
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Transforming Growth Factor, beta receptor 2 (AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII) is a member of the TGF-beta family of receptor Serine/Threonine kinases. It is involved in the regulation of cell proliferation. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). TGFBR2 encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. TGFBR2 also has a pseudogene on chromosome 14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ser/Thr protein kinase; tgf beta receptor 2; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta RII; TGFBR2-SE; TGFR-2; TGFR2; transforming growth factor beta receptor II; transforming growth factor beta receptor II (70/80kDa) isoform TGFBR2_1; transforming growth factor beta receptor II (70/80kDa) isoform TGFBR2_2; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma; Transforming growth factor-beta receptor type II; unnamed protein product
Gene Aliases: AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; tbetaR-II; TBR-ii; TBRII; TGFbeta-RII; TGFBR2; TGFR-2
UniProt ID: (Human) P37173
Entrez Gene ID: (Human) 7048
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type II
protein binding
ATP binding
glycosaminoglycan binding
kinase activity
activin receptor activity, type I
transferase activity
kinase activator activity
type I transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding
signaling receptor activity
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding
binding, bridging
blood vessel development
patterning of blood vessels
vasculogenesis
in utero embryonic development
epithelial to mesenchymal transition
heart looping
positive regulation of mesenchymal cell proliferation
lens development in camera-type eye
positive regulation of tolerance induction to self antigen
positive regulation of B cell tolerance induction
positive regulation of T cell tolerance induction
outflow tract septum morphogenesis
membranous septum morphogenesis
outflow tract morphogenesis
aortic valve morphogenesis
atrioventricular valve morphogenesis
tricuspid valve morphogenesis
cardiac left ventricle morphogenesis
endocardial cushion fusion
growth plate cartilage development
growth plate cartilage chondrocyte growth
apoptotic process
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
Notch signaling pathway
smoothened signaling pathway
gastrulation
nervous system development
brain development
heart development
positive regulation of cell proliferation
response to xenobiotic stimulus
regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of epithelial to mesenchymal transition
cell differentiation
lung development
activin receptor signaling pathway
response to lipid
embryonic hemopoiesis
aorta morphogenesis
regulation of cell proliferation
myeloid dendritic cell differentiation
positive regulation of angiogenesis
animal organ development
blood vessel morphogenesis
embryonic cranial skeleton morphogenesis
artery morphogenesis
positive regulation of developmental process
positive regulation of NK T cell differentiation
cartilage development
regulation of multicellular organismal process
palate development
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
ventricular septum morphogenesis
lung morphogenesis
bronchus development
bronchus morphogenesis
trachea morphogenesis
trachea formation
mammary gland morphogenesis
lung lobe morphogenesis
Langerhans cell differentiation
secondary palate development
response to cholesterol
cellular response to growth factor stimulus
regulation of stem cell proliferation
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
cell proliferation involved in endocardial cushion morphogenesis
superior endocardial cushion morphogenesis
inferior endocardial cushion morphogenesis
lens fiber cell apoptotic process
miRNA transport
positive regulation of reactive oxygen species metabolic process
positive regulation of CD4-positive, alpha-beta T cell proliferation
regulation of stem cell differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support