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          • Primary Antibodies ›
          • TGFBR2 Antibodies

          Invitrogen

          TGFBR2 Polyclonal Antibody

          1 Published Figure
          1 Reference
          View all (32) TGFBR2 antibodies

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          Cite TGFBR2 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (4)
          • Published Figures (1)
          TGFBR2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          TGFBR2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 5

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          TGFBR2 Antibody (PA5-36115) in IHC (P)

          Immunohistochemistry analysis of TGFBR2 in paraffin-embedded human colorectal carcinoma tissue. Samples were incubated with TGFBR2 polyclonal antibody (Product # PA5-36115) using a dilution of 0.0763888888888889. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          View Product

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          TGFBR2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TGFBR2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TGFBR2 Antibody in Western Blot (WB)
          TGFBR2 Antibody in Western Blot (WB)
          TGFBR2 Antibody in Western Blot (WB)
          TGFBR2 Polyclonal Antibody

          Product Details

          PA5-36115

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          View 1 publication 1 publication

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide corresponding to amino acids 220-300 of human TGF beta RII
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.2, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2553377

          Product Specific Information

          This antibody detects endogenous protein at a molecular weight of 65 kDa.

          Purity is >95% by SDS-PAGE.

          Target Information

          Transforming Growth Factor, beta receptor 2 (AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII) is a member of the TGF-beta family of receptor Serine/Threonine kinases. It is involved in the regulation of cell proliferation. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). TGFBR2 encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. TGFBR2 also has a pseudogene on chromosome 14.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: Ser/Thr protein kinase; tbetaR-II; tgf beta receptor 2; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta RII; TGFBR2-SE; TGFR-2; TGFR2; transforming growth factor beta receptor II; transforming growth factor beta receptor II (70/80kDa) isoform TGFBR2_1; transforming growth factor beta receptor II (70/80kDa) isoform TGFBR2_2; transforming growth factor beta receptor type II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor IIT; transforming growth factor-b type II receptor; Transforming growth factor-beta receptor type II; transforming growth factor-beta type II receptor; unnamed protein product

          View more View less

          Gene Aliases: 1110020H15Rik; AAT3; AU042018; DNIIR; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; RIIDN; TAAD2; TbetaR-II; TbetaRII; TBR-II; TBRII; TGF-beta 2; TGFbeta-RII; TGFBR2; Tgfbr2T; TGFR-2

          View more View less

          UniProt ID: (Human) P37173, (Rat) P38438, (Mouse) Q62312

          View more View less

          Entrez Gene ID: (Human) 7048, (Rat) 81810, (Mouse) 21813

          View more View less

          Function(s)
          nucleotide binding protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type II protein binding ATP binding glycosaminoglycan binding kinase activity activin receptor activity, type I transferase activity kinase activator activity type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding signaling receptor activity SMAD binding metal ion binding activin binding transforming growth factor beta binding binding, bridging receptor signaling protein serine/threonine kinase activity mitogen-activated protein kinase kinase kinase binding protein homodimerization activity protein heterodimerization activity receptor activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
          Process(es)
          blood vessel development patterning of blood vessels vasculogenesis in utero embryonic development epithelial to mesenchymal transition heart looping positive regulation of mesenchymal cell proliferation lens development in camera-type eye positive regulation of tolerance induction to self antigen positive regulation of B cell tolerance induction positive regulation of T cell tolerance induction outflow tract septum morphogenesis membranous septum morphogenesis outflow tract morphogenesis aortic valve morphogenesis atrioventricular valve morphogenesis tricuspid valve morphogenesis cardiac left ventricle morphogenesis endocardial cushion fusion growth plate cartilage development growth plate cartilage chondrocyte growth apoptotic process transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway Notch signaling pathway smoothened signaling pathway gastrulation nervous system development brain development heart development positive regulation of cell proliferation response to xenobiotic stimulus regulation of gene expression positive regulation of epithelial cell migration positive regulation of epithelial to mesenchymal transition cell differentiation lung development activin receptor signaling pathway response to lipid embryonic hemopoiesis aorta morphogenesis regulation of cell proliferation myeloid dendritic cell differentiation positive regulation of angiogenesis animal organ development blood vessel morphogenesis embryonic cranial skeleton morphogenesis artery morphogenesis positive regulation of developmental process positive regulation of NK T cell differentiation cartilage development regulation of multicellular organismal process palate development positive regulation of SMAD protein import into nucleus SMAD protein signal transduction ventricular septum morphogenesis lung morphogenesis bronchus development bronchus morphogenesis trachea morphogenesis trachea formation mammary gland morphogenesis lung lobe morphogenesis Langerhans cell differentiation secondary palate development response to cholesterol cellular response to growth factor stimulus regulation of stem cell proliferation positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation cell proliferation involved in endocardial cushion morphogenesis superior endocardial cushion morphogenesis inferior endocardial cushion morphogenesis lens fiber cell apoptotic process miRNA transport positive regulation of reactive oxygen species metabolic process positive regulation of CD4-positive, alpha-beta T cell proliferation regulation of stem cell differentiation response to hypoxia protein phosphorylation receptor-mediated endocytosis common-partner SMAD protein phosphorylation embryo implantation aging response to nutrient negative regulation of cell proliferation response to mechanical stimulus response to glucose organ morphogenesis response to organic substance response to organic cyclic compound peptidyl-serine phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation organ regeneration activation of protein kinase activity wound healing response to drug positive regulation of skeletal muscle tissue regeneration response to estrogen response to steroid hormone digestive tract development positive regulation of smooth muscle cell proliferation negative regulation of cardiac muscle cell proliferation pathway-restricted SMAD protein phosphorylation phosphorylation regulation of growth
          It has to be done as per old AB suggested Products section.

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