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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 264 and 330 of Human TGR5|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-27076 targets TGR5 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-27076 immunogen is synthetic peptide corresponding to a region within amino acids 264 and 330 of Human TGR5.
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BG37; G-protein coupled bile acid receptor BG37; G-protein coupled receptor GPCR19; GPCR19; GPR131; hGPCR19; M-BAR; membrane bile acid receptor; membrane-type receptor for bile acids; TGR5
BG37; GPBAR1; GPCR19; GPR131; M-BAR; TGR5