PA5-27076 targets TGR5 in IHC (P) and WB applications and shows reactivity with Human samples.
PA5-27076 targets TGR5 in IHC applications and shows reactivity with Mouse adrenal gland samples.
The PA5-27076 immunogen is synthetic peptide corresponding to a region within amino acids 264 and 330 of Human TGR5.
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This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.
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Protein Aliases: BG37; G-protein coupled bile acid receptor 1; G-protein coupled bile acid receptor BG37; G-protein coupled receptor GPCR19; GPCR19; GPR131; hBG37; hGPCR19; M-BAR; membrane bile acid receptor; Membrane-type receptor for bile acids; TGR5
Gene Aliases: BG37; GPBAR1; GPCR19; GPR131; M-BAR; TGR5
UniProt ID: (Human) Q8TDU6
Entrez Gene ID: (Human) 151306