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Rockland
THAP11 Polyclonal Antibody
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Product Details
600-401-FD7
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-THAP11 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid peptide near the C-terminus of human THAP11.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes two proteins, the SART1protein expressed in the nucleus of the majority of proliferating cells, and the SART1protein expressed in the cytosol of epithelial cancers. The SART1protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HRIHFB2206; Ronin; THAP domain-containing protein 11; unnamed protein product
Gene Aliases: 2810036E22Rik; AB041579; CTG-B43a; CTG-B45d; HRIHFB2206; MAHCL; MNCb-2032; RONIN; SCA51; THAP11
UniProt ID: (Human) Q96EK4, (Mouse) Q9JJD0
Entrez Gene ID: (Human) 57215, (Mouse) 59016, (Rat) 307806
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
zinc ion binding
metal ion binding
nucleic acid binding
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
cell proliferation
electron transport chain
neuron differentiation
negative regulation of neuron apoptotic process
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription from mitochondrial promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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