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Invitrogen
TIA-1 Polyclonal Antibody
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FIGURE: 1 / 6
TIA-1 Antibody (PA5-18699) in ICC/IF
Immunocytochemistry analysis of TIA-1 using TIA-1 Polyclonal Antibody (Product # PA5-18699) in paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (5 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing nuclear and some cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (5 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
Product Details
PA5-18699
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
C. elegans
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (PKSTYESNTKQ) corresponding to the internal amino acids of TIA1 (aa 189-200).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cytotoxic granule associated RNA binding protein TIA1; cytotoxic granule-associated RNA-binding protein 1; Nucleolysin TIA-1; Nucleolysin TIA-1 isoform p40; p40 TIA 1; p40-TIA-1; p40-TIA-1 (containing p15-TIA-1); RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA 1; TIA-1; TIA1 protein; TIAL1; TIAR
Gene Aliases: 2310050N03Rik; AI256674; mTIA-1; Tia; TIA-1; TIA1; WDM
UniProt ID: (Human) P31483, (Mouse) P52912
Entrez Gene ID: (Human) 7072, (Mouse) 21841
apoptotic process
fibroblast growth factor receptor signaling pathway
negative regulation of translation
negative regulation of cytokine biosynthetic process
regulation of mRNA splicing, via spliceosome
protein localization to cytoplasmic stress granule
positive regulation of epithelial cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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