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Proteintech
TIAM2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
26870-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TIAM2 fusion protein Ag25469
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: KDLELTVFVF KRAVILVYKE NCKLKKKLPS NSRPAHNSTD LDPFKFRWLI PISALQVRLG NPAGTENNSI WELIHTKSEI EGRPETIFQL CCSDSESKTN IVKVIRSILR ENFRRHIKCE LPLEKTCKDR LVPLKNRVPV SAKLASSRSL KVLKNSSSNE WTGETGKGTL LDSDEGSLSS GTQSSGCPTA EGRQDSKSTS PGKYPHPGLA DFADNLIKES DILSDEDDDH RQTVKQGSPT KDIEIQFQRL RISEDPDVHP EAEQQPGPES GEGQKGGEQP KLVRGHFCPI KRKANSTKRD RGTLLKAQIR HQSLDSQSEN ATIDLNSVLE REFSVQSLTS VVSEECFYET ESHGKS
Target Information
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1; SIF and TIAM1-like exchange factor; similar to TIAM1; STEF; T cell lymphoma invasion and metastasis 2; T-cell lymphoma invasion and metastasis 2; T-cell lymphoma invasion and metastasis 2; RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1; T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2; unnamed protein product
Gene Aliases: 3000002F19Rik; mKIAA2016; STEF; TIAM-2
UniProt ID: (Human) Q8IVF5, (Mouse) Q6ZPF3
Entrez Gene ID: (Human) 26230, (Mouse) 24001, (Rat) 100362710
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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