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Abnova
TIAM2 Polyclonal Antibody, MaxPab™
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Product Details
H00026230-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TIAM2 (NP_001010927, 1 a.a. approximately 626 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MEGPRENQDP PPRPLARHLS DADRLRKVIQ ELVDTEKSYV KDLSCLFELY LEPLQNETFL TQDEMESLFG SLPEMLEFQK VFLETLEDGI SASSDFNTLE TPSQFRKLLF SLGGSFLYYA DHFKLYSGFC ANHIKVQKVL ERAKTDKAFK AFLDARNPTK QHSSTLESYL IKPVQRVLKY PLLLKELVSL TDQESEEHYH LTEALKAMEK VASHINEMQK IYEDYGTVFD QLVAEQSGTE KEVTELSMGE LLMHSTVSWL NPFLSLGKAR KDLELTVFVF KRAVILVYKE NCKLKKKLPS NSRPAHNSTD LDPFKFRWLI PISALQVRLG NPAGTENNSI WELIHTKSEI EGRPETIFQL CCSDSESKTN IVKVIRSILR ENFRRHIKCE LPLEKTCKDR LVPLKNRVPV SAKLASSRSL KVLKNSSSNE WTGETGKGTL LDSDEGSLSS GTQSSGCPTA EGRQDSKSTS PGKYPHPGLA DFADNLIKES DILSDEDDDH RQTVKQGSPT KDIEIQFQRL RISEDPDVHP EAEQQPGPES GEGQKGGEQP KLVRGHFCPI KRKANSTKRD RGTLLKAQIR HQSLDSQSEN ATIDLNSVLE REFSVQSLTS VVSEECFYET ESHGKS
Target Information
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Rho guanine nucleotide exchange factor TIAM2; SIF and TIAM1-like exchange factor; similar to TIAM1; STEF; T cell lymphoma invasion and metastasis 2; T-cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2; unnamed protein product
Gene Aliases: KIAA2016; STEF; TIAM-2; TIAM2
UniProt ID: (Human) Q8IVF5
Entrez Gene ID: (Rat) 100362710, (Human) 26230
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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