Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1; Rho guanine nucleotide exchange factor TIAM2; SIF and TIAM1-like exchange factor; T-cell lymphoma invasion and metastasis 2; T-cell lymphoma invasion and metastasis 2; RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1; T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2
Gene Aliases: 3000002F19Rik; KIAA2016; mKIAA2016; STEF; TIAM-2; TIAM2
UniProt ID: (Human) Q8IVF5, (Mouse) Q6ZPF3
Entrez Gene ID: (Human) 26230, (Mouse) 24001
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support