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Invitrogen
TICAM2 Monoclonal Antibody (757706)
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Product Details
MA5-61424
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
757706
Immunogen
E. coli-derived recombinant mouse TRAM/TICAM2, Met1-Ala232
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
TRAM, or TRIF-related adaptor molecule (TICAM2), plays an essential role in the MyD88-independent signaling of TLR4. The functional absence of TRAM in vascular endothelial cells restricts TLR4 signaling to MyD88-dependent pathway. Overexpression of TRAM cDNA in endothelial cells reconstituted LPS-induced Trif-dependent NF-kB activation and cxcl10 promoter activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: TAG; TICAM-2; TIR domain-containing adapter molecule 2; TIR domain-containing adapter protein; Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2; Toll/interleukin-1 receptor domain-containing protein; TRIF-related adapter molecule; TRIF-related adapter molecule TRAM; TRIF-related adaptor molecule
Gene Aliases: B430113A10; TICAM-2; Ticam2; Tirp; TRAM; Trif
UniProt ID: (Mouse) Q8BJQ4
Entrez Gene ID: (Mouse) 225471
regulation of cytokine production
immune system process
inflammatory response
signal transduction
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
negative regulation of toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
TRAM-dependent toll-like receptor 4 signaling pathway
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
regulation of interferon-beta biosynthetic process
response to interleukin-12
cellular response to lipopolysaccharide
negative regulation of chemokine (C-C motif) ligand 5 production
positive regulation of chemokine (C-C motif) ligand 5 production
positive regulation of interleukin-18-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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