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Fabgennix

TIE2 Polyclonal Antibody, FITC

View all (50) TIE2 (TEK) antibodies

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TIE2 Polyclonal Antibody, FITC

Product Details

TIE2-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-

Dot blot (DB)

1:10,000
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 540-590 on human Tyrosine-protein kinase receptor Tie-1 isoform 2 protein.
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD202b antigen; cell surface receptor homolog; EC 2.7.10; EC 2.7.10.1; endothelial tyrosine kinase; endothelial-specific receptor tyrosine kinase; p140 TEK; TEK tyrosine kinase, endothelial; TEKT1; Tektin-1; tunica interna endothelial cell kinase; tyrosine kinase with Ig and EGF homology domains-2; tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2; tyrosine-protein kinase receptor TEK; tyrosine-protein kinase receptor TIE-2

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Gene Aliases: Cd202b; Hyk; STK1; Tie-2; Tie2

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UniProt ID: (Mouse) Q02858

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Entrez Gene ID: (Rat) 89804, (Mouse) 21687

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding transmembrane receptor protein kinase activity growth factor binding signaling receptor activity identical protein binding protein binding
Process(es)
angiogenesis vasculogenesis response to hypoxia positive regulation of protein phosphorylation endothelial cell proliferation regulation of endothelial cell proliferation endochondral ossification sprouting angiogenesis positive regulation of cytokine production involved in immune response cell-matrix adhesion cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway heart development positive regulation of signal transduction positive regulation of endothelial cell migration negative regulation of angiogenesis peptidyl-tyrosine phosphorylation hemopoiesis regulation of cell migration cell-substrate adhesion response to retinoic acid regulation of establishment or maintenance of cell polarity positive regulation of peptidyl-serine phosphorylation substrate adhesion-dependent cell spreading positive regulation of Rac protein signal transduction positive regulation of Rho protein signal transduction positive regulation of protein import into nucleus negative regulation of apoptotic process positive regulation of MAPK cascade response to peptide hormone response to estrogen regulation of angiogenesis positive regulation of angiogenesis positive regulation of cell adhesion Tie signaling pathway branching morphogenesis of an epithelial tube positive regulation of multicellular organismal process response to cAMP positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling heart trabecula formation positive regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus cell-cell adhesion regulation of NIK/NF-kappaB signaling regulation of intracellular signal transduction positive regulation of intracellular signal transduction regulation of endothelial cell apoptotic process negative regulation of endothelial cell apoptotic process patterning of blood vessels positive regulation of vascular endothelial growth factor receptor signaling pathway glomerulus vasculature development
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