CC3 (HTATIP2) is a member of the short-chain dehydrogenases/reductases (SDR) family. It is a novel serine/threonine kinase that phosphorylates the C-terminal domain (CTD) of the largest RNA polymerase II subunit and induces the expression of apoptosis related genes Bad and Siva, as well as metastasis suppressor NM23-H2. It also interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates ERalpha-mediated c-myc transcription.
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Protein Aliases: 30 kDa HIV-1 TAT-interacting protein; FLJ26963; HIV-1 tat interactive protein 2, 30 kDa homolog; HIV-1 Tat interactive protein 2, 30kDa; HIV-1 tat interactive protein 2, homolog; HIV-1 TAT-interactive protein 2; HTATIP2; Oxidoreductase HTATIP2; short chain dehydrogenase/reductase family 44U, member 1; Tat-interacting protein (30kD); tat-interacting protein 30 kDa
Gene Aliases: AW111545; CC3; HTATIP2; SDR44U1; TIP30