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TIRAP Polyclonal Antibody

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Product Details

200-401-FF3

Applications
Tested Dilution
Publications

Western Blot (WB)

4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

20 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-

ELISA (ELISA)

1:40,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Anti-TIRAP antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to amino acids near the internal region of human TIRAP.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-βB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adapter protein wyatt; Adaptor protein Wyatt; FLJ42305; HGNC:17192; MAL; MyD88 adapter-like protein; MyD88-2; OTTHUMP00000179130; TIR domain-containing adapter protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Toll-like receptor adaptor protein; Toll/interleukin-1 receptor domain-containing adapter protein; unnamed protein product

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Gene Aliases: BACTS1; MAL; MyD88-2; TIRAP; wyatt

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UniProt ID: (Human) P58753

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Entrez Gene ID: (Human) 114609

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Function(s)
protein kinase C binding protein binding phosphatidylinositol-4,5-bisphosphate binding protein binding, bridging signaling adaptor activity Toll-like receptor 4 binding Toll-like receptor 2 binding identical protein binding binding, bridging
Process(es)
immune system process MyD88-dependent toll-like receptor signaling pathway inflammatory response signal transduction cell surface receptor signaling pathway myeloid cell differentiation positive regulation of B cell proliferation positive regulation of protein complex assembly response to lipopolysaccharide regulation of interferon-beta production positive regulation of interleukin-12 production positive regulation of interleukin-15 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor 2 signaling pathway positive regulation of toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway positive regulation of toll-like receptor 4 signaling pathway TIRAP-dependent toll-like receptor 4 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of innate immune response positive regulation of JNK cascade defense response to Gram-positive bacterium positive regulation of ERK1 and ERK2 cascade 3'-UTR-mediated mRNA stabilization cellular response to bacterial lipopeptide cellular response to lipoteichoic acid positive regulation of neutrophil chemotaxis positive regulation of chemokine (C-X-C motif) ligand 1 production positive regulation of chemokine (C-X-C motif) ligand 2 production
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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