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Invitrogen
TMED5 Polyclonal Antibody
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FIGURE: 1 / 3
TMED5 Antibody (PA5-144635) in IHC (P)
Immunohistochemistry of TMED5 in paraffin-embedded mouse large intestine tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 2 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with TMED5 polyclonal antibody (Product # PA5-144635) with a dilution of 1:5,000 for 1 hour at roo... View More
Product Details
PA5-144635
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within Human TMED5 aa 1-200/229.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive control: Rat liver tissue lysate, A431 cell lysate, Jurkat cell lysate, Hela cell lysate, SiHa cell lysate, rat bladder tissue, mouse large intestine tissue.
Predicted band size: 26 kDa
Subcellular Location: Cis-Golgi network membrane, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane.
Target Information
The TMED5 gene encodes the transmembrane emp24 domain-containing protein 5, a member of the TMED family, which is involved in intracellular protein trafficking. This family is essential for the transport of proteins between the endoplasmic reticulum and the Golgi apparatus. TMED5 is a member of the γ subfamily and has been shown to regulate vital cellular processes, including protein secretion and signal transduction. Dysregulation of TMED5 has been implicated in various diseases, including hepatocellular carcinoma (HCC). Increased expression of TMED5 mRNA in HCC tissues is associated with poorer overall survival rates compared to normal tissues, suggesting its role in tumor progression and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p24 family protein gamma-2; p24gamma2; p28; Transmembrane emp24 domain-containing protein 5; transmembrane emp24 protein transport domain containing 5; unnamed protein product
Gene Aliases: 3110020O18Rik; 4432412D15Rik; CGI-100; LRRG00120; p24g2; p28; TMED5; UNQ397/PRO733
UniProt ID: (Human) Q9Y3A6, (Rat) Q6AXN3, (Mouse) Q9CXE7
Entrez Gene ID: (Human) 50999, (Rat) 289883, (Mouse) 73130
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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