Peptide sequence: IHSVCLPAAT QNIPPGSTAY VTGWGAQEYA GHTVPELRQG QVRIISNDVC
Sequence homology: Human: 100%
The interleukin 17 receptor E (IL-17RE) shares limited similarity to the receptor of IL-17A, a ubiquitous type I membrane glycoprotein that with IL-17A plays a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL-17RE is the functional receptor of IL-17C and has been suggested to mediate mucosal immunity to infection with intestinal pathogens. IL-17C is produced by epithelia in response to bacterial challenge and binds to a receptor complex formed by IL-17RE and IL-17RA on the epithelial cell surface, thereby regulating the immune function of epithelial cells in an autocrine manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: airway trypsin like protease; Airway trypsin-like protease; HAT; MGC150587; MGC150588; serine 11D; Transmembrane protease; Transmembrane protease serine 11D; Transmembrane protease serine 11D catalytic chain; Transmembrane protease serine 11D non-catalytic chain
Gene Aliases: HAT; TMPRSS11D
UniProt ID: (Human) O60235
Entrez Gene ID: (Human) 9407
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule