TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter. The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
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Protein Aliases: matriptase 2; Matriptase-2; membrane-bound mosaic serine proteinase matriptase-2; Transmembrane protease serine 6; transmembrane protease, serine 6; transmembrane serine protease 6; type II transmembrane serine protease 6
Gene Aliases: 1300008A22Rik; IRIDA; TMPRSS6; UNQ354/PRO618
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule