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Proteintech
TMPRSS6 Polyclonal Antibody
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Product Details
12950-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TMPRSS6 Fusion Protein Ag4076 (76-375 aa encoded by BC039082)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LGYKAEVMV SQVYSGSLRV LNRHFSQDLT RRESSAFRSE TAKAQKMLKE LITSTRLGTY YNSSSVYSFG EGPLTCFFWF ILQIPEHRRL MLSPEVVQAL LVEELLSTVN SSAAVPYRAE YEVDPEGLVI LEASVKDIAA LNSTLGCYRY SYVGQGQVLR LKGPDHLASS CLWHLQGPKD LMLKLRLEWT LAECRDRLAM YDVAGPLEKR LITSVYGCSR QEPVVEVLAS GAIMAVVWKK GLHSYYDPFV LSVQPVVFQA CEVNLTLDNR LDSQGVLSTP YFPSYYSPQT HCSWHLTVPS L (76-375 aa encoded by BC039082)
Target Information
TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter. The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dJ1170K4.2; matriptase 2; Matriptase-2; membrane-bound mosaic serine proteinase matriptase-2; Transmembrane protease serine 6; transmembrane protease, serine 6; transmembrane serine protease 6; type II transmembrane serine protease 6
Gene Aliases: 1300008A22Rik; IRIDA; MT2; TMPRSS6; UNQ354/PRO618
UniProt ID: (Human) Q8IU80, (Mouse) Q9DBI0
Entrez Gene ID: (Human) 164656, (Rat) 315388, (Mouse) 71753
negative regulation of transcription from RNA polymerase II promoter
proteolysis
cellular iron ion homeostasis
extracellular matrix disassembly
BMP signaling pathway
negative regulation of BMP signaling pathway
collagen catabolic process
membrane protein proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
multicellular organismal iron ion homeostasis
self proteolysis
biological_process
fibrinolysis
iron ion homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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