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Invitrogen
TMPRSS6 Polyclonal Antibody
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FIGURE: 1 / 3
TMPRSS6 Antibody (PA5-143873) in WB
Western blot analysis of TMPRSS6 using TMPRSS6 antibody (Product # PA5-143873). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 µg of sample under reducing conditions. Lane 1: human HCCT tissue lysates; Lane 2: rat brain tissue lysates; Lane 3: mouse brain tissue lysates; Lane 4: rat liver tissue lysates; Lane 5: mouse liver tissue lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA f... View More
Product Details
PA5-143873
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human Matriptase 2/TMPRSS6 recombinant protein (Position: M1-Q759).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human HCCT tissue, rat brain tissue, mouse brain tissue, rat liver tissue, mouse liver tissue. Flow: MCF-7 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter. The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dJ1170K4.2; matriptase 2; Matriptase-2; membrane-bound mosaic serine proteinase matriptase-2; Transmembrane protease serine 6; transmembrane protease, serine 6; transmembrane serine protease 6; type II transmembrane serine protease 6
Gene Aliases: 1300008A22Rik; IRIDA; MT2; TMPRSS6; UNQ354/PRO618
UniProt ID: (Human) Q8IU80, (Mouse) Q9DBI0
Entrez Gene ID: (Human) 164656, (Rat) 315388, (Mouse) 71753
negative regulation of transcription from RNA polymerase II promoter
proteolysis
cellular iron ion homeostasis
extracellular matrix disassembly
BMP signaling pathway
negative regulation of BMP signaling pathway
collagen catabolic process
membrane protein proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
multicellular organismal iron ion homeostasis
self proteolysis
biological_process
fibrinolysis
iron ion homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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