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Predicted to react with Human samples.
Tumor necrosis factor, α-induced protein 8-like 1, also known as TNFα-IP 8L1, is a 186 amino acid protein belonging to the TNFα-IP 8 family. Members of the TNFα-IP 8 family are induced by nuclear factor-κB 9 (NFκB) and tumor necrosis factor (TNF), although induction by TNF is dependent upon NFκB activation. TNFα-IP 8 proteins also act as a negative mediator of apoptosis and may play a role in tumor progression. They suppress TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Oxidative stress regulated gene-beta; Oxidative stress-regulated gene-beta; Oxy-beta; TIPE1; TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1; Tumor necrosis factor alpha-induced protein 8-like protein 1; tumor necrosis factor, alpha induced protein 8 like 1; tumor necrosis factor, alpha-induced protein 8-like 1; tumor necrosis factor, alpha-induced protein 8-like protein 1
Gene Aliases: 2600017J23Rik; TIPE1; TNFAIP8L1
UniProt ID: (Human) Q8WVP5, (Mouse) Q8K288
Entrez Gene ID: (Human) 126282, (Mouse) 66443
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