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Abnova
TNFRSF1B Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 2
TNFRSF1B Antibody (H00007133-D01P) in WB
Western Blot analysis of TNFRSF1B expression in transfected 293T cell line (H00007133-T01) by TNFRSF1B MaxPab polyclonal antibody.
Lane 1: TNFRSF1B transfected lysate(48.30 KDa).
Lane 2: Non-transfected lysate.
Lane 1: TNFRSF1B transfected lysate(48.30 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00007133-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TNFRSF1B (NP_001057.1, 1 a.a. approximately 461 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA QMCCSKCSPG QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC SSDQVETQAC TREQNRICTC RPGWYCALSK QEGCRLCAPL RKCRPGFGVA RPGTETSDVV CKPCAPGTFS NTTSSTDICR PHQICNVVAI PGNASMDAVC TSTSPTRSMA PGAVHLPQPV STRSQHTQPT PEPSTAPSTS FLLPMGPSPP AEGSTGDFAL PVGLIVGVTA LGLLIIGVVN CVIMTQVKKK PLCLQREAKV PHLPADKARG TQGPEQQHLL ITAPSSSSSS LESSASALDR RAPTRNQPQA PGVEASGAGE ARASTGSSDS SPGGHGTQVN VTCIVNVCSS SDHSSQCSSQ ASSTMGDTDS SPSESPKDEQ VPFSKEECAF RSQLETPETL LGSTEEKPLP LGVPDAGMKP S
Target Information
TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha. It has a much lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most of the metabolic effects of TNF-alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 75-kda; CD120b; p75; p75 TNF receptor; p75 TNFR; p80 TNF-alpha receptor; sCD120b; soluble CD120b; soluble TNFR2; sTNF R2; sTNFR 2; sTNFR2; TNF receptor beta chain; TNF-R2; TNF-RII; TNFR; TNFR II; TNFR-II; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor; Tumor necrosis factor receptor 2; tumor necrosis factor receptor protein (TNFR); Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor type II
Gene Aliases: CD120b; p75; p75TNFR; TBPII; TNF-alphaR2; TNF-R-II; TNF-R2; TNF-R75; TNFalpha-R2; TNFBR; Tnfr-1; Tnfr-2; TNFR1B; TNFR2; TNFR80; TNFRII; TNFRSF1B
UniProt ID: (Human) P20333, (Mouse) P25119
Entrez Gene ID: (Human) 7133, (Mouse) 21938
regulation of cytokine production involved in immune response
regulation of T cell cytokine production
aortic valve development
pulmonary valve development
negative regulation of extracellular matrix constituent secretion
apoptotic process
inflammatory response
cell surface receptor signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of cardiac muscle hypertrophy
regulation of myelination
positive regulation of myelination
tumor necrosis factor-mediated signaling pathway
regulation of T cell proliferation
positive regulation of oligodendrocyte differentiation
negative regulation of inflammatory response
RNA destabilization
positive regulation of membrane protein ectodomain proteolysis
cellular response to lipopolysaccharide
extrinsic apoptotic signaling pathway
regulation of neuroinflammatory response
negative regulation of neuroinflammatory response
glial cell-neuron signaling
positive regulation of apoptotic process involved in morphogenesis
immune response
cell proliferation
programmed cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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