FIGURE: 1 / 8
Immunogen sequence: MAASRRSQH HHHHHQQQLQ PAPGASAPPP PPPPPLSPGL APGTTPASPT ASGLAPFASP RHGLALPEGD GSRDPPDRPR SPDQVDGTSC CSTTSTICTV AAAPVVPAVS TSSAAGVAPN PAGSGSNNSP SSSSSPTSSS SSSPSSPGSS LAESPEAAGV SSTAPLGPGA AGPGTGVPAV SGALRELLEA CRNGDVSRVK RLVDAANVNA KDMAGRKSSP LHFAAGFGRK DVVEHLLQMG ANVHARDDGG LIPLHNACSF GHAEVVSLLL CQGADPNARD NWNYTPLHEA AIKGKIDVCI VLLQHGADPN IRNTDGKSAL DLADPSAKAV (1-329 aa encoded by BC098394)
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADP-ribosyltransferase diphtheria toxin-like 5; ARTD5; HGNC:11941; Poly [ADP-ribose] polymerase 5A; Poly [ADP-ribose] polymerase tankyrase-1; Protein poly-ADP-ribosyltransferase tankyrase-1; TANK1; tankyrase 1; Tankyrase I; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; Tankyrase-1; TNKS-1; TRF1-interacting ankyrin-related ADP-ribose polymerase; TRF1-interacting ankyrin-related ADP-ribose polymerase 1
Gene Aliases: 4930554K12Rik; AI662855; ARTD5; C86528; D130072O21Rik; mTNKS1; PARP-5a; PARP5A; PARPL; pART5; TANK1; TIN1; TINF1; TNKS; TNKS1
Molecular Function: kinase inhibitor