Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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Protein Aliases: importin 3; IPO3; karyopherin (importin) beta 2b; Karyopherin beta 2b; karyopherin beta 2b, transportin; Karyopherin beta-2b; KPNB2B; TNPO2; transportin 2; transportin 2 (importin 3, karyopherin beta 2b); Transportin-2; TRN2
Gene Aliases: 1110034O24Rik; AA414969; AI464345; AI852433; IPO3; Knpb2b; KPNB2B; TNPO2; TRN2