The antibody recognizes all isoforms of TNS3.
The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring actin filaments at the focal adhesion via F-actin binding and capping activities. Tns proteins also contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting a role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns3, also known as TEM6 or TENS1, localizes to the focal adhesions of the plasma membrane. It is predominantly expressed in thyroid and placenta but can also be found in heart, liver, brain, prostate, pancreas, kidney, lung, skeletal muscle and white blood cells. Tns3 is essential for proper growth and development, as suggested by growth retardation and death in a number of Tns3-/- mice.
Protein Aliases: TENS3; Tensin-3; tensin-like SH2 domain containing 1; tensin-like SH2 domain-containing 1; Tensin-like SH2 domain-containing protein 1; thyroid specific PTB domain protein; Tumor endothelial marker 6
Gene Aliases: BC023928; F830010I22Rik; RGD1564174; TEM6; TENS1; tensin3; TNS3; TPP; TSN3
Molecular Function: non-motor actin binding protein