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Invitrogen
TNXB Polyclonal Antibody
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FIGURE: 1 / 4
TNXB Antibody (PA5-80173) in ICC/IF
Immunocytochemistry analysis of TNXB using anti-TNXB antibody (Product # PA5-80173). TNXB was detected in a section of MCF7 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 2μg/mL rabbit anti-TNXB antibody (Product # PA5-80173) overnight at 4°C. DyLight®594 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visual... View More
Product Details
PA5-80173
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human TNXB (3309-3337aa DLRAVAVSGLDPARKYKFLLFGLQNGKRH).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: MCF-7 whole cell, SW620 whole cell, HELA whole cell. IHC: human placenta tissue. ICC/IF: MCF7 cell. Flow: Hela cell.
Target Information
Tenascin-X (TNXB) is a extracellular matrix glycoprotein predominantly located in the outer reticular lamina of the basement membrane (BM). It interacts with many other ECM proteins and it accelerates collagen fibrillogenesisin vitro. TNXB plays a role in interactions between cell and ECM, antiadhesive effect, inhibiting cell migration, and in maintaining homeostasis of the extracellular matrix. Deficiency of TNXB has been associated with the connective tissue disorder Ehlers-Danlos syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GIG45; growth-inhibiting protein 45; Hexabrachion-like protein; tenascin XB1; tenascin XB2; Tenascin-X; TN-X; TNXB2tenascin XB1; TNXBSTNXTENX; unidentified protein; XB-S; XBTN-X
Gene Aliases: EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X; TNX; TNXB; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS
UniProt ID: (Human) P22105
Entrez Gene ID: (Human) 7148
lipid metabolic process
fatty acid metabolic process
triglyceride metabolic process
cell adhesion
cell-matrix adhesion
positive regulation of cell proliferation
positive regulation of epithelial to mesenchymal transition
actin cytoskeleton organization
regulation of cell adhesion
extracellular matrix organization
collagen fibril organization
regulation of cell migration
neuron projection development
collagen metabolic process
regulation of cell differentiation
regulation of JNK cascade
elastic fiber assembly
cell-cell adhesion
positive regulation of vascular endothelial growth factor signaling pathway
positive regulation of collagen fibril organization
positive regulation of cell fate determination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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