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Product Details
14915-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TOB1 Fusion Protein Ag6714 (1-345 aa encoded by BC031406)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
14915-1-AP recognizes 38 and 45 kDa bands. The additional 45 kDa band may be due to phosphorylation.
Immunogen sequence: MQLEIQVAL NFIISYLYNK LPRRRVNIFG EELERLLKKK YEGHWYPEKP YKGSGFRCIH IGEKVDPVIE QASKESGLDI DDVRGNLPQD LSVWIDPFEV SYQIGEKGPV KVLYVDDNNE NGCELDKEIK NSFNPEAQVF MPISDPASSV SSSPSPPFGH SAAVSPTFMP RSTQPLTFTT ATFAATKFGS TKMKNSGRSN KVARTSPINL GLNVNDLLKQ KAISSSMHSL YGLGLGSQQQ PQQQQQPAQP PPPPPPPQQQ QQQKTSALSP NAKEFIFPNM QGQGSSTNGM FPGDSPLNLS PLQYSNAFDV FAAYGGLNEK SFVDGLNFSL NNMQYSNQQF QPVMAN (1-345 aa encoded by B C031406)
Target Information
This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC104792; MGC34446; proliferation-inducing gene 49; Protein Tob1; Transducer of erbB-2 1; transducer of erbB2; transducer of ERBB2, 1
Gene Aliases: APRO5; APRO6; PIG49; TOB; TOB1; TROB; TROB1
UniProt ID: (Human) P50616, (Mouse) Q61471
Entrez Gene ID: (Human) 10140, (Mouse) 22057, (Rat) 170842
SMAD protein import into nucleus
negative regulation of cell proliferation
negative regulation of translation
negative regulation of BMP signaling pathway
negative regulation of osteoblast differentiation
negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of nucleic acid-templated transcription
positive regulation of signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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