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Invitrogen
TOMM22 Polyclonal Antibody
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FIGURE: 1 / 1
TOMM22 Antibody (PA5-89898) in WB
Western blot analysis of TOMM22 in extracts of various cell lines. Samples were incubated with TOMM22 Polyclonal antibody (Product # PA5-89898) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-89898
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-83 of human TOMM22 (NP_0646281)
Conjugate
Form
Liquid
Concentration
1.92 mg/mL
Amount
192 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAAAVAAAGA GEPQSPDELL PKGDAEKPEE ELEEDDDEEL DETLSERLWG LTEMFPERVR SAAGATFDLS LFVAQKMYRF SRA; Positive Samples: HeLa, HepG2, K-562; Cellular Location: Mitochondrion outer membrane, Single-pass membrane protein
Target Information
Tom22 has a negatively charged N-terminal region exposed to the cytosol, a putative transmembrane region, and a C-terminal intermembrane space region with little negative charge. The following functions can be assigned to the three domains of Tom22: the cytosolic N-terminal domain plays a dual role, specifically important for presequence binding; the intermembrane space domain provides a trans binding site for presequences, and the single membrane anchor of Tom22 is crucial for the integrity of the GIP (general import gene) complex. The TOM complex of mammalian mitochondria resembles the fungal Tom complex, but is distinct from the plant TOM system. Thus, while unique components of the mammalian mitochondrial import system have been identified (e. g. TOM34 and metaxin), Tom22, and Tom37 have not been identified in plant mitochondria.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1C9-2; dJ508I15.5; hTom22; Mitochondrial import receptor subunit TOM22 homolog; mitochondrial import receptor Tom22; Translocase of outer membrane 22 kDa subunit homolog; translocase of outer mitochondrial membrane 22 homolog; unnamed protein product
Gene Aliases: 1C9-2; 2310047D01; MST065; MSTP065; TOM22; TOMM22
UniProt ID: (Human) Q9NS69, (Mouse) Q9CPQ3
Entrez Gene ID: (Human) 56993, (Mouse) 223696
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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