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Proteintech
TOPBP1 Polyclonal Antibody
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Product Details
23340-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TOPBP1 Fusion Protein Ag18961 (1-335 aa encoded by BC126209)
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MHHQRCVPR AEHPVYNMVM SDVTISCTSL EKEKREEVHK YVQMMGGRVY RDLNVSVTHL IAGEVGSKKY LVAANLKKPI LLPSWIKTLW EKSQEKKITR YTDINMEDFK CPIFLGCIIC VTGLCGLDRK EVQQLTVKHG GQYMGQLKMN ECTHLIVQEP KGQKYECAKR WNVHCVTTQW FFDSIEKGFC QDESIYKTEP RPEAKTMPNS STPTSQINTI DSRTLSDVSN ISNINASCVS ESICNSLNSK LEPTLENLEN LDVSAFQAPE DLLDGCRIYL CGFSGRKLDK LRRLINSGGG VRFNQLNEDV THVIVGDYDD ELKQFWNKSA HRPHVV (1-335 aa encoded by B C126209)
Target Information
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; KIAA0259; TOPBP 1; TopBP1; topoisomerase (DNA) II binding protein 1; unnamed protein product
Gene Aliases: Dpb11; KIAA0259; TOP2BP1; TOPBP1
UniProt ID: (Human) Q92547
Entrez Gene ID: (Human) 11073
DNA replication checkpoint
DNA damage checkpoint
double-strand break repair via homologous recombination
DNA metabolic process
DNA replication initiation
DNA repair
double-strand break repair
chromatin organization
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
response to ionizing radiation
mitotic DNA replication checkpoint
reciprocal DNA recombination
chromosome organization
double-strand break repair via classical nonhomologous end joining
double-strand break repair via alternative nonhomologous end joining
broken chromosome clustering
protein localization to site of double-strand break
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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