Invitrogen

TOPORS Polyclonal Antibody

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

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Protocols

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TOPORS Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of TOPORS in human testis tissue shows strong nuclear and granular cytoplasmic positivity in cells in seminiferous ducts and Leydig cells. Samples were probed using a TOPORS Polyclonal Antibody (Product # PA5-64234).

TOPORS Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of TOPORS demonstrates antibody specificity. Immunohistochemical analysis of TOPORS using anti-TOPORS Polyclonal Antibody (Product # PA5-64234), shows significant staining of TOPORS in human testis and shows minimal or weak staining in human pancreas tissues. The relative expression levels of TOPORS within each tissue is shown using RNA-Seq. {RE}

Product Details

PA5-64234

Applications	Tested Dilution	Publications
Immunohistochemistry (IHC)	1:200-1:500	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Recombinant protein corresponding to Human TOPORS View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.1 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.2, with 40% glycerol
Contains	0.02% sodium azide
Storage conditions	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID	AB_2648823

Product Specific Information

Immunogen sequence: IVQHIIMSNV TRYDLESQAF VSDLRPFLLN RTEHFIHEFI SFARSPFNMA AFDQHANYDC PAPSYEEGSH SDSSVITISP DEAETQELDI NVATVSQAPW DDETPGPSYS SSEQVHVTMS SLL

Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 91%.

Target Information

Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase Topors; p53-binding protein 3; RING-type E3 ubiquitin transferase Topors; SUMO1-protein E3 ligase Topors; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; Topoisomerase I-binding arginine/serine-rich protein; Topoisomerase I-binding RING finger protein; Tumor suppressor p53-binding protein 3

Gene Aliases: LUN; P53BP3; RP31; TOPORS; TP53BPL

UniProt ID: (Human) Q9NS56

Entrez Gene ID: (Human) 10210

Molecular Function: ubiquitin-protein ligase