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Invitrogen

TPR Polyclonal Antibody

View all (15) TPR antibodies
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
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Product Details

Tested Applications
Dilution
Immunocytochemistry (ICC)
1-4 µg/mL
Immunofluorescence (IF)
1-4 µg/mL
Immunohistochemistry (IHC)
1:200-1:500
Western Blot (WB)
0.4 µg/mL
Product Specifications
Species Reactivity
Human
Host / Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TPR
Conjugate
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2648855

Product Specific Information

Immunogen sequence: KMASVRQHLE ETTQKAESQL LECKASWEER ERMLKDEVSK CVCRCEDLEK QNRLLHDQIE KLSDKVVASV KEGVQGPLNV SLSEEGKSQE

Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.

Target Information

This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Megator; NPC-associated intranuclear protein; nuclear basket protein; nuclear pore complex-associated protein TPR; Nucleoprotein TPR; translocated promoter region; translocated promoter region (to activated MET oncogene); Translocated promoter region protein; tumor potentiating region

Gene Aliases: TPR

UniProt ID: (Human) P12270

Entrez Gene ID: (Human) 7175

Function(s)
negative regulation of transcription from RNA polymerase II promoter MAPK import into nucleus RNA import into nucleus RNA export from nucleus mRNA export from nucleus tRNA export from nucleus protein import into nucleus protein export from nucleus nuclear pore organization mitotic nuclear division mitotic nuclear envelope disassembly mitotic spindle assembly checkpoint biological_process regulation of mRNA export from nucleus regulation of glucose transport regulation of mitotic sister chromatid separation viral process protein sumoylation viral transcription gene silencing by RNA positive regulation of heterochromatin assembly regulation of protein stability mRNA export from nucleus in response to heat stress cellular response to heat cellular response to interferon-alpha regulation of protein import into nucleus positive regulation of protein import into nucleus nuclear matrix organization negative regulation of translational initiation regulation of protein export from nucleus positive regulation of protein export from nucleus negative regulation of RNA export from nucleus nuclear pore complex assembly cell division response to epidermal growth factor intracellular transport of virus positive regulation of mitotic cell cycle spindle assembly checkpoint positive regulation of intracellular protein transport regulation of cellular response to heat regulation of mitotic spindle assembly
Process(es)
molecular_function chromatin binding mRNA binding transporter activity nucleocytoplasmic transporter activity protein binding tubulin binding heat shock protein binding protein homodimerization activity protein anchor poly(A) RNA binding mitogen-activated protein kinase binding dynein complex binding

Suggested Secondary Antibodies

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