|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 19 amino acid peptide near the center of human TPT1|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||25 ug/ml|
|Western Blot (WB)||0.5 - 1 ug/mL|
A suggested positive control is human brain tissue lysate.
PA5-34503 can be used with blocking peptide PEP-1546.
TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer"e;s disease and Down syndrome.
21 kDa polypeptide under translational control; fortilin; histamine-releasing factor; HRF; lens epithelial protein; TCTP; TPT1; translationally regulated transcript (21 kDa); translationally-controlled tumor protein; Tumor protein translationally-controlled 1
HRF; p02; p21; p23; TCTP; TPT1; Trt