Immunogen sequence: MGSVLSTDSG KSAPASATAR ALERRRDPEL PVTSFDCAVC LEVLHQPVRT RCGHVFCRSC IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYKNC AECDT; Positive Samples: Mouse testis
TRAC-1 is a 232 amino acid protein containing an N-terminal RING-type zinc finger domain. It functions as a positive regulator in the T-cell receptor signaling pathway, thus leading to T-cell activation. It mediates ubiquitination and subsequent proteasomal degradation of target proteins. TRAC-1 is expressed in lymphoid tissues, including bone marrow, spleen, thymus as well as in other tissues. It is predominantly expressed in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells.
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Protein Aliases: E3 ubiquitin-protein ligase RNF125; RING finger protein 125
Gene Aliases: 4930553F04Rik; Rnf125
UniProt ID: (Mouse) Q9D9R0
Entrez Gene ID: (Mouse) 67664
Molecular Function: ubiquitin-protein ligase