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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||TRAIL-R4 (aa 1-210) - hIgGhc fusion protein|
|Storage buffer||PBS with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD264; DCR2; Decoy receptor 2; TNF receptor-related receptor for TRAIL; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL receptor with a truncated death domain; TRAIL-R4; TRAILR4; TRUNDD; Tumor necrosis factor receptor superfamily member 10D; tumor necrosis factor receptor superfamily member 10d, decoy with truncated death domain; tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
CD264; DCR2; TNFRSF10D; TRAIL-R4; TRAILR4; TRUNDD; UNQ251/PRO288